Biotherapeutic proteins represent a mainstay of treatment for a multitude of conditions, for
example, autoimmune disorders, hematologic disorders, hormonal dysregulation, cancers …

Over the last years, the biopharmaceutical industry has significantly turned its biologics
production towards mammalian cell expression systems. The presence of glycosylation …

Understanding the impact of glycosylation and keeping a close control on glycosylation of
product candidates are required for both novel and biosimilar monoclonal antibodies (mAbs) …

Critical quality attributes (CQA) are physical, chemical, biological or microbiological
properties or characteristics that must be within an appropriate limit, range or distribution to …

A well known, epidemiologically reproducible risk factor for human carcinomas is the long-
term consumption of “red meat” of mammalian origin. Although multiple theories have …

A growing body of evidence supports crucial roles for glycans at various pathophysiological
steps of tumour progression. Glycans regulate tumour proliferation, invasion …

To date, more than 20 recombinant immunoglobulin G (IgG) antibody therapeutics are
licensed for the treatment of various diseases. The mechanism of action of recombinant …

The question whether dietary habits and lifestyle have influence on the course of multiple
sclerosis (MS) is still a matter of debate, and at present, MS therapy is not associated with …

The wide occurrence of sialic acids (Sia) in various chemical forms linked as monomers or
polymers in an outstanding position in a multitude of complex carbohydrates of animals and …

Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased heart
valves but their susceptibility to structural valve degeneration (SVD) limits their use in young …