Graphene-based nanomaterials (GBNs) have been the subject of research focus in the
scientific community because of their excellent physical, chemical, electrical, mechanical …

Lymphocytes maturing in the thymus (T cells) are key factors in adaptive immunity and the
regulation of inflammation. The kynurenine pathway of tryptophan metabolism includes …

The importance of the kynurenine pathway in normal immune system function has led to an
appreciation of its possible contribution to autoimmune disorders such as rheumatoid …

Privileged structures are conductive to discover novel bioactive substances because they
can bind to multiple targets with high affinity. Quinones are considered to be a privileged …

Conversion of tryptophan to N-formylkynurenine is the first and rate-limiting step of the
tryptophan metabolic pathway (ie, the kynurenine pathway). This conversion is catalyzed by …

Simple Summary There is clear evidence that inflammation can contribute to the
development of cancers, but the underlying mechanisms are not fully understood. This …

In our quest to design and develop N/O-containing inhibitors of α-amylase, we have tried to
synergize the inhibitory action of 1, 4-naphthoquinone, imidazole and 1, 2, 3-triazole motifs …

Indoleamine 2, 3-dioxygenase 1 (IDO1) catalyzes the rate-limiting step in the kynurenine
pathway of tryptophan metabolism, which is involved in immunity, neuronal function, and …

Indoleamine 2, 3-dioxygenase 1 (IDO1) has received increasing attention due to its
immunosuppressive function in connection with various diseases, including cancer. A recent …

Survivin is a novel attractive target for cancer therapy; however, it is considered undruggable
because it lacks enzymatic activities. Herein, we describe our efforts toward the discovery of …