The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions

V Carlini, DM Noonan, E Abdalalem, D Goletti… - Frontiers in …, 2023 - frontiersin.org
Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …

Pathophysiological mechanisms of thrombosis in acute and long COVID-19

H Jing, X Wu, M Xiang, L Liu, VA Novakovic… - Frontiers in …, 2022 - frontiersin.org
COVID-19 patients have a high incidence of thrombosis, and thromboembolic complications
are associated with severe COVID-19 and high mortality. COVID-19 disease is associated …

Pro- and Anti-Inflammatory Prostaglandins and Cytokines in Humans: A Mini Review

JL Wautier, MP Wautier - International Journal of Molecular Sciences, 2023 - mdpi.com
Inflammation has been described for two millennia, but cellular aspects and the paradigm
involving different mediators have been identified in the recent century. Two main groups of …

Vascular endothelial glycocalyx damage and potential targeted therapy in COVID-19

D Zha, M Fu, Y Qian - Cells, 2022 - mdpi.com
COVID-19 is a highly infectious respiratory disease caused by a new coronavirus known as
SARS-CoV-2. COVID-19 is characterized by progressive respiratory failure resulting from …

Recent advances and evolving concepts in Still's disease

P Ruscitti, L Cantarini, PA Nigrovic… - Nature Reviews …, 2024 - nature.com
Still's disease is a rare inflammatory syndrome that encompasses systemic juvenile
idiopathic arthritis and adult-onset Still's disease, both of which can exhibit life-threatening …

Dysregulated immune responses in SARS-CoV-2-infected patients: a comprehensive overview

I Kudryavtsev, A Rubinstein, A Golovkin, O Kalinina… - Viruses, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in
humans more than two years ago and caused an unprecedented socio-economic burden on …

Investigating the impact of severe maternal SARS-CoV-2 infection on infant DNA methylation and neurodevelopment

RA Hill, A Gibbons, W Suwakulsiri, A Taseska… - Molecular …, 2024 - nature.com
Maternal infections during pregnancy can increase the risk to offspring of developing a
neurodevelopmental disorder. Given the global prevalence and severity of infection with …

Therapeutic implications of current Janus kinase inhibitors as anti-COVID agents: A review

NK Jain, M Tailang, HK Jain… - Frontiers in …, 2023 - frontiersin.org
Severe cases of COVID-19 are characterized by hyperinflammation induced by cytokine
storm, ARDS leading to multiorgan failure and death. JAK-STAT signaling has been …

Sarilumab administration in COVID-19 patients: Literature review and considerations

A Marino, A Munafò, E Augello, CM Bellanca… - Infectious Disease …, 2022 - mdpi.com
Two years have passed since WHO declared a pandemic state for SARS-CoV-2 infection.
COVID-19 pathogenesis consists of a first viral phase responsible for early symptoms …

Effects of Sulforaphane on SARS‑CoV‑2 infection and NF‑κB dependent expression of genes involved in the COVID‑19 'cytokine storm'

J Gasparello, G Marzaro, C Papi… - International …, 2023 - spandidos-publications.com
Since its spread at the beginning of 2020, the coronavirus disease 2019 (COVID‑19)
pandemic represents one of the major health problems. Despite the approval, testing, and …