[HTML][HTML] Neurobiology and consequences of social isolation stress in animal model—A comprehensive review

F Mumtaz, MI Khan, M Zubair, AR Dehpour - Biomedicine & …, 2018 - Elsevier
The brain is a vital organ, susceptible to alterations under genetic influences and
environmental experiences. Social isolation (SI) acts as a stressor which results in …

The role of magnesium in neurological disorders

AE Kirkland, GL Sarlo, KF Holton - Nutrients, 2018 - mdpi.com
Magnesium is well known for its diverse actions within the human body. From a neurological
standpoint, magnesium plays an essential role in nerve transmission and neuromuscular …

[HTML][HTML] NeoDTI: neural integration of neighbor information from a heterogeneous network for discovering new drug–target interactions

F Wan, L Hong, A Xiao, T Jiang, J Zeng - Bioinformatics, 2019 - academic.oup.com
Results Inspired by recent advance of information passing and aggregation techniques that
generalize the convolution neural networks to mine large-scale graph data and greatly …

Glutamate receptor ion channels: structure, regulation, and function

SF Traynelis, LP Wollmuth, CJ McBain, FS Menniti… - Pharmacological …, 2010 - Elsevier
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

The molecular basis of retinal ganglion cell death in glaucoma

M Almasieh, AM Wilson, B Morquette… - Progress in retinal and …, 2012 - Elsevier
Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

GE Hardingham, H Bading - Nature Reviews Neuroscience, 2010 - nature.com
There is a long-standing paradox that NMDA (N-methyl-d-aspartate) receptors (NMDARs)
can both promote neuronal health and kill neurons. Recent studies show that NMDAR …

Excitotoxicity: bridge to various triggers in neurodegenerative disorders

A Mehta, M Prabhakar, P Kumar, R Deshmukh… - European journal of …, 2013 - Elsevier
Glutamate is one of the most prominent neurotransmitter in the body, present in over 50% of
nervous tissue and plays an important role in neuronal excitation. This neuronal excitation is …

Early management of severe traumatic brain injury

JV Rosenfeld, AI Maas, P Bragge… - The Lancet, 2012 - thelancet.com
Severe traumatic brain injury remains a major health-care problem worldwide. Although
major progress has been made in understanding of the pathophysiology of this injury, this …

Brain NMDA receptors in schizophrenia and depression

A Adell - Biomolecules, 2020 - mdpi.com
N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP),
dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia …

GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction

G Lesca, G Rudolf, N Bruneau, N Lozovaya… - Nature …, 2013 - nature.com
Epileptic encephalopathies are severe brain disorders with the epileptic component
contributing to the worsening of cognitive and behavioral manifestations. Acquired epileptic …