Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell–matrix
interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and …

Regulated changes in protein conformation can have profound effects on protein function,
although routine laboratory methods often fail to detect them. The recently discovered BAG …

Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) influences cytotoxicity,
translocating to the nucleus during apoptosis. Here we report a signalling pathway in which …

Phosphorylation of p53 at Ser 46 was shown to regulate p53 apoptotic activity. Here we
demonstrate that homeodomain-interacting protein kinase-2 (HIPK2), a member of a novel …

Heat Shock Protein 70 kDa (Hsp70) family molecular chaperones play critical roles in
protein folding and trafficking in all eukaryotic cells. The mechanisms by which Hsp70 family …

Destruction of β-catenin is regulated through phosphorylation-dependent interactions with
the F box protein β-TrCP. A novel pathway for β-catenin degradation was discovered …

The BAG-1 protein modulates the chaperone activity of Hsc70 and Hsp70 in the mammalian
cytosol and nucleus. Remarkably, BAG-1 possesses a ubiquitin-like domain at its amino …

Abstract Hypoxia-inducible factor-1α (HIF1α) is a central regulator of the cellular response to
hypoxia. Prolyl-hydroxylation of HIF1α by PHD enzymes is prerequisite for HIF1α …

Dysregulation of pleiotropic growth factors, receptors and their downstream signaling
pathway components represent a central protumorigenic principle in human …

The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and
GSK3β, forms a Wnt-regulated signaling complex that mediates phosphorylation-dependent …