Implications of phosphoinositide 3-kinase-Akt (PI3K-Akt) pathway in the pathogenesis of Alzheimer's disease

M Kumar, N Bansal - Molecular neurobiology, 2022 - Springer
Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …

Oxidative stress in cognitive and epigenetic aging: a retrospective glance

A Kandlur, K Satyamoorthy… - Frontiers in molecular …, 2020 - frontiersin.org
Brain aging is the critical and common factor among several neurodegenerative disorders
and dementia. Cellular, biochemical and molecular studies have shown intimate links …

Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury

VV Andrianov, VA Kulchitsky, GG Yafarova, LV Bazan… - Molecules, 2023 - mdpi.com
Nitric oxide (NO) production in injured and intact brain regions was compared by EPR
spectroscopy in a model of brain and spinal cord injury in Wistar rats. The precentral gyrus of …

[PDF][PDF] Protective effects of L-arginine on cognitive deficits and biochemical parameters in an experimental model of type-2 diabetes mellitus induced Alzheimer's …

H Dubey, A Dubey, K Gulati, A Ray - Journal of Physiology & …, 2022 - researchgate.net
Alzheimer's disease (AD) has been closely linked to type 2 diabetes mellitus (T2DM) and
insulin resistance plays a key role in the onset and development of AD. It has also been …

Alzheimer's disease: A contextual link with nitric oxide synthase

H Dubey, K Gulati, A Ray - Current Molecular Medicine, 2020 - ingentaconnect.com
Nitric oxide (NO) is a gasotransmitter with pleiotropic effects which has made a great impact
on biology and medicine. A multidimensional neuromodulatory role of NO has been shown …

S-nitrosoglutathione modulates HDAC2 and BDNF levels in the brain and improves cognitive deficits in experimental model of Alzheimer's disease in rats

H Dubey, A Dubey, K Gulati, A Ray - International Journal of …, 2024 - Taylor & Francis
Aim Alzheimer's disease (AD) is a neurodegenerative disorder which is characterized by
cognitive deficits and abnormal memory formation. Histone acetylation is essential for …

Protective effects of L-arginine on Alzheimer's disease: Modulating hippocampal nitric oxide levels and memory deficits in aluminum chloride-induced rat model

S Geravand, M Karami, H Sahraei, F Rahimi - European Journal of …, 2023 - Elsevier
There is evidence that high daily intake of aluminum (Al) is associated with an increased risk
of dementia or cognitive decline. We injected L-arginine into the dorsal hippocampus (DH) …

Leaf extract of Anacardium occidentale ameliorates biomarkers of neuroinflammation, memory loss, and neurobehavioral deficit in N(ω)-nitro-L-arginine methyl ester …

AA Oyagbemi, AK Adebayo, OE Adebiyi, KO Adigun… - Biomarkers, 2023 - Taylor & Francis
Purpose Anacardium occidentale commonly known as Cashew is a plant that is widely used
in African traditional medicine. It is endowed with phytochemical constituents that are …

Metabolic Syndrome and Associated Cognitive Dysfunction: A Pharmacological Perspective

K Gulati, H Dubey, A Tanwar, A Arora, A Ray - … Mechanisms for Metabolic …, 2024 - Springer
Metabolic syndrome (Met-S) is an interrelated complex disease which involves physical,
metabolic and endocrinal dysfunction and is associated with increased risk of …

The effect of nitric oxide on spatial learning and memory impairment following rapid eye movement (REM) sleep deprivation in rats

M Bodagh, M Taati - Feyz Medical Sciences Journal, 2023 - feyz.kaums.ac.ir
Methods: In this experimental study, 50 rats were divided into five groups: control, sleep
deprivation, sleep deprivation plus triple doses of 100, 200 and 300 mg/kg L-arginine …