Recent progress in the science of complex coacervation

CE Sing, SL Perry - Soft Matter, 2020 - pubs.rsc.org
Complex coacervation is an associative, liquid–liquid phase separation that can occur in
solutions of oppositely-charged macromolecular species, such as proteins, polymers, and …

50th Anniversary Perspective: A Perspective on Polyelectrolyte Solutions

M Muthukumar - Macromolecules, 2017 - ACS Publications
From the beginning of life with the information-containing polymers until the present era of a
plethora of water-based materials in health care industry and biotechnology, polyelectrolytes …

Detecting and quantifying liquid–liquid phase separation in living cells by model-free calibrated half-bleaching

F Muzzopappa, J Hummert, M Anfossi… - Nature …, 2022 - nature.com
Cells contain numerous substructures that have been proposed to form via liquid–liquid
phase separation (LLPS). It is currently debated how to reliably distinguish LLPS from other …

Multiphase complex coacervate droplets

T Lu, E Spruijt - Journal of the American Chemical Society, 2020 - ACS Publications
Liquid–liquid phase separation plays an important role in cellular organization. Many
subcellular condensed bodies are hierarchically organized into multiple coexisting domains …

Polyelectrolyte complex coacervates: Recent developments and new frontiers

AM Rumyantsev, NE Jackson… - Annual Review of …, 2021 - annualreviews.org
Polyelectrolyte complex coacervates represent a wide class of materials with applications
ranging from coatings and adhesives to pharmaceutical technologies. They also underpin …

Driving force and pathway in polyelectrolyte complex coacervation

S Chen, ZG Wang - … of the National Academy of Sciences, 2022 - National Acad Sciences
There is notable discrepancy between experiments and coarse-grained model studies
regarding the thermodynamic driving force in polyelectrolyte complex coacervation …

RNA stores tau reversibly in complex coacervates

X Zhang, Y Lin, NA Eschmann, H Zhou, JN Rauch… - PLoS …, 2017 - journals.plos.org
Nonmembrane-bound organelles that behave like liquid droplets are widespread among
eukaryotic cells. Their dysregulation appears to be a critical step in several …

Complex coacervate‐based materials for biomedicine

WC Blocher, SL Perry - Wiley Interdisciplinary Reviews …, 2017 - Wiley Online Library
There has been increasing interest in complex coacervates for deriving and transporting
biomaterials. Complex coacervates are a dense, polyelectrolyte‐rich liquid that results from …

Coacervate droplets for synthetic cells

Z Lin, T Beneyton, JC Baret, N Martin - Small Methods, 2023 - Wiley Online Library
The design and construction of synthetic cells–human‐made microcompartments that mimic
features of living cells–have experienced a real boom in the past decade. While many efforts …

Development of the modern theory of polymeric complex coacervation

CE Sing - Advances in colloid and interface science, 2017 - Elsevier
Oppositely charged polymers can undergo the process of complex coacervation, which
refers to a liquid–liquid phase separation driven by electrostatic attraction. These materials …