Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications
X Zhong, X He, Y Wang, Z Hu, H Huang, S Zhao… - Journal of hematology & …, 2022 - Springer
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …
[HTML][HTML] Metformin: Is it a drug for all reasons and diseases?
CR Triggle, I Mohammed, K Bshesh, I Marei, K Ye… - Metabolism, 2022 - Elsevier
Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …
first-choice drug used daily by approximately 150 million people. An accumulation of …
NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance
Glucose metabolism is known to orchestrate oncogenesis. Whether glucose serves as a
signaling molecule directly regulating oncoprotein activity for tumorigenesis remains elusive …
signaling molecule directly regulating oncoprotein activity for tumorigenesis remains elusive …
[HTML][HTML] Bioplastic (PHBV) addition to soil alters microbial community structure and negatively affects plant-microbial metabolic functioning in maize
Microplastic contamination poses a significant threat to agroecosystem functioning,
provoking a move away from the use of conventional oil-based plastics in agriculture, to …
provoking a move away from the use of conventional oil-based plastics in agriculture, to …
Altered metabolism in cancer: Insights into energy pathways and therapeutic targets
M Tufail, CH Jiang, N Li - Molecular Cancer, 2024 - Springer
Cancer cells undergo significant metabolic reprogramming to support their rapid growth and
survival. This study examines important metabolic pathways like glycolysis, oxidative …
survival. This study examines important metabolic pathways like glycolysis, oxidative …
Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity
Microglia continuously survey the brain parenchyma and actively shift status following
stimulation. These processes demand a unique bioenergetic programme; however, little is …
stimulation. These processes demand a unique bioenergetic programme; however, little is …
A global picture: therapeutic perspectives for COVID-19
VP Chavda, C Kapadia, S Soni, R Prajapati… - …, 2022 - Taylor & Francis
The COVID-19 pandemic is a lethal virus outbreak by severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2), which has severely affected human lives and the global …
coronavirus-2 (SARS-CoV-2), which has severely affected human lives and the global …
Targeting glucose metabolism enzymes in cancer treatment: current and emerging strategies
Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …
Mitochondrial remodeling in colorectal cancer initiation, progression, metastasis, and therapy: A review
NM Abdelmaksoud, AI Abulsoud… - … -Research and Practice, 2023 - Elsevier
Colorectal cancer (CRC) is a major health concern with multifactorial pathophysiology
representing intense therapeutic challenges. It is well known that deregulation of …
representing intense therapeutic challenges. It is well known that deregulation of …
An investigation on the molecular structure, interaction with metal clusters, anti-Covid-19 ability of 2-deoxy-D-glucose: DFT calculations, MD and docking simulations
Studies of the geometrical, vibration, absorption and physicochemical properties of 2-deoxy-
D-glucose with and without metal clusters are reported using the DFT method. 2-Deoxy-D …
D-glucose with and without metal clusters are reported using the DFT method. 2-Deoxy-D …