The macromolecule that carries genetic information, DNA, is considered as an exceptional
target for diseases depending on cellular division of malignant cells (ie cancer), microbes (ie …

Abstract Pyrrole–imidazole polyamides (Py–Im polyamides) are cell-permeable compounds
that bind to the minor groove of double-stranded DNA in a sequence-specific manner …

Many cancer therapeutics target DNA and exert cytotoxicity through the induction of DNA
damage and inhibition of transcription. We report that a DNA minor groove binding hairpin …

In the natural cellular environment, nucleic acid biomolecules like DNA have biological
implications via structural modifications and through precise coordination with other …

Recent innovations in cutting-edge sequencing platforms have allowed the rapid
identification of genes associated with communicable, noncommunicable and rare diseases …

Cellular reprogramming involves profound alterations in genome-wide gene expression that
is precisely controlled by a hypothetical epigenetic code. Small molecules have been shown …

The influential role of the epigenome in orchestrating genome-wide transcriptional activation
instigates the demand for the artificial genetic switches with distinct DNA sequence …

Recently, the versatility of N‐methylpyrrole (Py)‐N‐methylimidazole (Im) polyamide
conjugates, which have been developed from the DNA‐binding antibiotics distamycin A and …

To optimize the biological activity of pyrrole–imidazole polyamide DNA-binding molecules,
we characterized the aggregation propensity of these compounds through dynamic light …

Development of multifunctional transcriptional activators is of increasing importance as they
could trigger complicated gene networks. Recently, we developed a differential gene …