Treatment of low-risk gestational trophoblastic neoplasia

MC Winter - Best Practice & Research Clinical Obstetrics & …, 2021 - Elsevier
Low-risk gestational trophoblastic neoplasia (GTN), defined as FIGO/WHO score 0–6, is
highly curable with an overall survival rate, which is approximately 100%. For most low-risk …

[HTML][HTML] Practical clinical guidelines of the EOTTD for treatment and referral of gestational trophoblastic disease

C Lok, N van Trommel, L Massuger, F Golfier… - European Journal of …, 2020 - Elsevier
Background and aim Gestational trophoblastic disease (GTD) is a heterogeneous group of
disorders characterised by abnormal proliferation of trophoblastic tissue. Since GTD and its …

Management of trophoblastic tumors: review of evidence, current practice, and future directions

A Deleuze, C Massard, F Le Du, B You… - Expert Review of …, 2023 - Taylor & Francis
Introduction Gestational trophoblastic neoplasia (GTN) is a group of rare tumors
characterized by abnormal trophoblastic proliferation following pregnancy including invasive …

Treatment outcomes for 618 women with gestational trophoblastic tumours following a molar pregnancy at the Charing Cross Hospital, 2000–2009

A Sita-Lumsden, D Short, I Lindsay, NJ Sebire… - British Journal of …, 2012 - nature.com
Background: Post-molar pregnancy gestational trophoblastic tumours (GTT) have been
curable with chemotherapy treatment for over 50 years. Because of the rarity of the …

Effectiveness and toxicity of first-line methotrexate chemotherapy in low-risk postmolar gestational trophoblastic neoplasia: The New England Trophoblastic Disease …

I Maestá, R Nitecki, NS Horowitz, DP Goldstein… - Gynecologic …, 2018 - Elsevier
Objectives To assess the outcomes and toxicity of first-line methotrexate (MTX)
chemotherapy in low-risk postmolar gestational trophoblastic neoplasia (GTN) patients …

Relapse rates after two versus three consolidation courses of methotrexate in the treatment of low-risk gestational trophoblastic neoplasia

C Lybol, F Sweep, R Harvey, H Mitchell, D Short… - Gynecologic …, 2012 - Elsevier
OBJECTIVE: Methotrexate (MTX) alternating with folinic acid is a commonly used treatment
regimen for low-risk gestational trophoblastic neoplasia (GTN). In The Netherlands, two …

First-line hysterectomy for women with low-risk non-metastatic gestational trophoblastic neoplasia no longer wishing to conceive

PA Bolze, M Mathe, T Hajri, B You, Y Dabi… - Gynecologic …, 2018 - Elsevier
Background Low-risk gestational trophoblastic neoplasia (GTN) patients (FIGO score≤ 6)
are generally treated with single agent chemotherapy (methotrexate or dactinomycin) …

Contribution of referent pathologists to the quality of trophoblastic diseases diagnosis

F Golfier, J Clerc, T Hajri, J Massardier… - Human …, 2011 - academic.oup.com
OBJECTIVE To evaluate the contribution of referent pathologists (RPs) to the quality of
diagnosis of trophoblastic diseases and to study the level of diagnostic agreement between …

Efficacy and safety of second-line 5-day dactinomycin in case of methotrexate failure for gestational trophoblastic neoplasia

C Prouvot, F Golfier, J Massardier, B You… - International Journal of …, 2018 - ijgc.bmj.com
Objective The objective of this study was to evaluate the characteristics and outcomes of
patients treated for gestational trophoblastic neoplasia (GTN) with second-line 5-day …

Early prediction of treatment resistance in low-risk gestational trophoblastic neoplasia using population kinetic modelling of hCG measurements

B You, R Harvey, E Henin, H Mitchell, F Golfier… - British journal of …, 2013 - nature.com
Background: In low-risk gestational trophoblastic neoplasia (GTN) patients, a predictive
marker for early identification of methotrexate (MTX) resistance would be useful. We …