The Buchwald–Hartwig amination after 25 years

R Dorel, CP Grugel, AM Haydl - … Chemie International Edition, 2019 - Wiley Online Library
The Pd‐catalyzed coupling of aryl (pseudo) halides and amines is one of the most powerful
approaches for the formation of C (sp2)− N bonds. The pioneering reports from Migita and …

Applications of palladium-catalyzed C–N cross-coupling reactions

P Ruiz-Castillo, SL Buchwald - Chemical reviews, 2016 - ACS Publications
Pd-catalyzed cross-coupling reactions that form C–N bonds have become useful methods to
synthesize anilines and aniline derivatives, an important class of compounds throughout …

General cross-coupling reactions with adaptive dynamic homogeneous catalysis

I Ghosh, N Shlapakov, TA Karl, J Düker, M Nikitin… - Nature, 2023 - nature.com
Cross-coupling reactions are among the most important transformations in modern organic
synthesis,–. Although the range of reported (het) aryl halides and nucleophile coupling …

Impact of cross-coupling reactions in drug discovery and development

MJ Buskes, MJ Blanco - Molecules, 2020 - mdpi.com
Cross-coupling reactions have played a critical role enabling the rapid expansion of
structure–activity relationships (SAR) during the drug discovery phase to identify a clinical …

Palladium catalyzed C–C and C–N bond forming reactions: an update on the synthesis of pharmaceuticals from 2015–2020

J Rayadurgam, S Sana, M Sasikumar… - Organic Chemistry …, 2021 - pubs.rsc.org
Some of the most prominent and promising catalysts in organic synthesis for the requisite
construction of C–C and C–N bonds are palladium (Pd) catalysts, which play a pivotal role in …

Large-scale applications of transition metal-catalyzed couplings for the synthesis of pharmaceuticals

J Magano, JR Dunetz - Chemical Reviews, 2011 - ACS Publications
Research in the mid 1960s to early 1970s sparked an evolution in the approach of synthetic
chemists toward the assembly of molecules. Inspired by known Wacker-type processes in …

Dialkylbiaryl phosphines in Pd-catalyzed amination: a user's guide

DS Surry, SL Buchwald - Chemical Science, 2011 - pubs.rsc.org
Dialkylbiaryl phosphines are a valuable class of ligand for Pd-catalyzed amination reactions
and have been applied in a range of contexts. This perspective attempts to aid the reader in …

Synthesis of 2D imine-linked covalent organic frameworks through formal transimination reactions

E Vitaku, WR Dichtel - Journal of the American Chemical Society, 2017 - ACS Publications
Covalent organic frameworks (COFs) are crystalline, permanently porous, two-dimensional
or three-dimensional polymers with tunable topology and functionality. COFs linked with …

Photochemical synthesis of anilines via Ni-catalyzed coupling of aryl halides with ammonium salts

G Song, DZ Nong, Q Li, Y Yan, G Li, J Fan… - ACS …, 2022 - ACS Publications
Easy, efficient, and economic synthesis of anilines remains an important challenge in
synthetic chemistry. In this study, a Ni (OAc) 2-bipyridine complex is shown to readily …

The complementary competitors: palladium and copper in C–N cross-coupling reactions

IP Beletskaya, AV Cheprakov - Organometallics, 2012 - ACS Publications
The C–N cross-coupling chemistry intensely developed since the late 1990s has supplied
synthesists with an overwhelming number of methods to effectively combine carbon and …