Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential

DR Telange, AT Patil, AM Pethe, H Fegade… - European Journal of …, 2017 - Elsevier
The apigenin-phospholipid phytosome (APLC) was developed to improve the aqueous
solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin. The APLC …

Natural antioxidants' effects on endoplasmic reticulum stress-related diseases

LM Reyes-Fermín, OE Aparicio-Trejo… - Food and Chemical …, 2020 - Elsevier
Endoplasmic reticulum (ER) stress is a normal molecular process induced by the over-
accumulation of misfolded or unfolded proteins. ER stress induces the unfolded protein …

Flavonoids and related compounds in non-alcoholic fatty liver disease therapy

S Pisonero-Vaquero… - Current medicinal …, 2015 - ingentaconnect.com
Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome,
is one of the most common chronic liver diseases, which may progress to fibrosis, cirrhosis …

Phospholipid complex-loaded self-assembled phytosomal soft nanoparticles: evidence of enhanced solubility, dissolution rate, ex vivo permeability, oral bioavailability …

DR Telange, NK Sohail, AT Hemke, PS Kharkar… - Drug Delivery and …, 2021 - Springer
In this study, self-assembled phytosomal soft nanoparticles encapsulated with phospholipid
complex (MPLC SNPs) using a combination of solvent evaporation and nanoprecipitation …

Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK …

Y Li, J Yang, MH Chen, Q Wang, MJ Qin, T Zhang… - Pharmacological …, 2015 - Elsevier
Ilexgenin A is a natural triterpenoid with beneficial effects on lipid disorders. This study
aimed to investigate the effects of ilexgenin A on endothelial homeostasis and its …

Anti-inflammatory and immunomodulatory activity of Mangifera indica L. reveals the modulation of COX-2/mPGES-1 axis and Th17/Treg ratio

A Saviano, F Raucci, GM Casillo, AA Mansour… - Pharmacological …, 2022 - Elsevier
In the context of inflammation and immunity, there are fragmented and observational studies
relating to the pharmacological activity of Mangifera indica L. and its main active component …

Kaempferol-phospholipid complex: formulation, and evaluation of improved solubility, in vivo bioavailability, and antioxidant potential of kaempferol

DR Telange, AT Patil, AM Pethe… - Journal of excipients …, 2016 - fisherpub.sjf.edu
The current work describes the formulation and evaluation of a phospholipid complex of
kaempferol toenhance the latter's aqueous solubility, in vitro dissolution rate, in vivo …

[PDF][PDF] Dietary carnosic acid suppresses hepatic steatosis formation via regulation of hepatic fatty acid metabolism in high-fat diet-fed mice

MY Park, ST Mun - Nutrition research and practice, 2013 - synapse.koreamed.org
In this study, we examined the hepatic anti-steatosis activity of carnosic acid (CA), a phenolic
compound of rosemary (Rosmarinus officinalis) leaves, as well as its possible mechanism of …

Comparative pharmacokinetic and tissue distribution profiles of four major bioactive components in normal and hepatic fibrosis rats after oral administration of …

T Yang, S Liu, CH Wang, YY Tao, H Zhou… - Journal of Pharmaceutical …, 2015 - Elsevier
Fuzheng Huayu recipe (FZHY) is a herbal product for the treatment of liver fibrosis approved
by the Chinese State Food and Drug Administration (SFDA), but its pharmacokinetics and …

Development of a novel UHPLC-MS/MS method for the quantification of corynoxeine: Application to pharmacokinetics and tissue distribution studies in normal and …

Q Sun, N Zhao, T Zhang, S Wang, L Wang… - Journal of Pharmaceutical …, 2024 - Elsevier
Corynoxeine, a natural active alkaloid found in Genus Uncaria, has been reported to have
anti-depressant effects. In this study, a sensitive and efficient ultra-high performance liquid …