Elimination or mitigation of the toxic effects of chemical waste released to the environment
by industrial and urban activities relies largely on the catalytic activities of microorganisms …

Novel techniques for acquiring metabolomics data continue to emerge. Such data require
proper storage in suitably configured databases, which then permit one to establish the size …

Understanding of the logic and dynamics of gene-regulatory and biochemical networks is a
major challenge of systems biology. To facilitate this research topic, we have developed a …

The use of animals in research and education dates back to the period when humans
started to look for ways to prevent and cure ailments. Most of present day's drug discoveries …

Biologists are increasingly recognising that computational modelling is crucial for making
sense of the vast quantities of complex experimental data that are now being collected. The …

Systems biology is an emerging discipline that combines high-content, multiplexed
measurements with informatic and computational modeling methods to better understand …

Several new methodologies have enabled recent studies on the microbial biodegradation
mechanisms of organic pollutants. Culture-independent techniques for analysis of the …

The dynamics of how the constituent components of a natural system interact defines the
spatio-temporal response of the system to stimuli. Modeling the kinetics of the processes that …

We present COMPUCELL3D, a software framework for three-dimensional simulation of
morphogenesis in different organisms. COMPUCELL3D employs biologically relevant …

Accurately translating genotype to phenotype requires accounting for the functional impact
of genetic variation at many biological scales. Here, we present a strategy for genotype …