It is now well accepted that plasma cells can become long-lived (memory) plasma cells and
secrete antibodies for months, years or a lifetime. However, the mechanisms involved in this …

Ectopic lymphoid neogenesis often occurs in the target tissues of patients with chronic
rheumatic autoimmune diseases such as rheumatoid arthritis, Sjögren syndrome and other …

Synovial tissue is a membranous non-immune organ lining joint cavities where it supports
local immune responses, and functions directly and indirectly in joint destruction due to …

High-throughput sequencing analysis of hypermutating immunoglobulin (IG) repertoires
remains a challenging task. Here we present a robust protocol for the full-length profiling of …

Ectopic lymphoid structures (ELS) often develop at sites of inflammation in target tissues of
autoimmune diseases, such as rheumatoid arthritis, Sjögren's syndrome, multiple sclerosis …

The pathogenesis of rheumatoid arthritis (RA) is a complex scenario that, to date, is not fully
elucidated. However, scientific progress has enabled us to understand several mechanisms …

The development of high-throughput DNA sequencing technologies has enabled large-
scale characterization of functional antibody repertoires, a new method of understanding …

As the key cellular effectors of adaptive immunity, T and B lymphocytes utilize specialized
receptors to recognize, respond to, and neutralize a diverse array of extrinsic threats. These …

Interstitial cystitis (IC) is a chronic bladder disease with urinary frequency, bladder discomfort
or bladder pain of unknown etiology. Based on cystoscopic findings, patients with IC are …

Fibroblast-like synoviocytes (FLSs) are important non-immune cells located mostly in the
inner layer of the synovium. Indeed, these cells are specialized mesenchymal cells …