Lipid droplets (LDs), once considered mere storage depots for lipids, have gained
recognition for their intricate roles in cellular processes, including metabolism, membrane …

Chemotherapy was conventionally applied to kill cancer cells, but regrettably, they also
induce damage to normal cells with high-proliferative capacity resulting in cardiotoxicity …

It has been 11 years since ferroptosis, a new mode of programmed cell death, was first
proposed. Natural products are an important source of drug discovery. In the past five years …

Strong evidence indicates that environmental stressors are the risk factors for male
testosterone deficiency (TD). However, the mechanisms of environmental stress-induced TD …

Cisplatin-induced hearing loss is a common side effect of cancer chemotherapy in clinics;
however, the mechanism of cisplatin-induced ototoxicity is still not completely clarified …

Cisplatin is a first-line chemotherapeutic agent in the treatment of malignant tumors with
remarkable clinical effects and low cost. However, the ototoxicity and neurotoxicity of …

Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron
dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have …

Cisplatin is widely used to treat various solid tumors. However, its toxicity to normal tissues
limits its clinical application, particularly due to its ototoxic effects, which can result in hearing …

Intracerebral hemorrhage (ICH) is a serious cerebrovascular disease with high rates of
morbidity, mortality, and disability. Optimal treatment of ICH is a major clinical challenge, as …

Ototoxicity is an often-underestimated sequela for cancer patients undergoing
chemotherapy, with an incidence rate exceeding 50%, affecting approximately 4 million …