Targeting SREBP-1-mediated lipogenesis as potential strategies for cancer

Q Zhao, X Lin, G Wang - Frontiers in oncology, 2022 - frontiersin.org
Sterol regulatory element binding protein-1 (SREBP-1), a transcription factor with a basic
helix–loop–helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from …

Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion and metastasis

J Zhang, Y Song, Q Shi, L Fu - Frontiers of medicine, 2021 - Springer
Tumorigenesis involves metabolic reprogramming and abnormal lipid metabolism, which is
manifested by increased endogenous fat mobilization, hypertriglyceridemia, and increased …

Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription

Y Wang, J Feng, L Zhao, M Zhao, X Wei… - Acta Pharmacologica …, 2023 - nature.com
A number of studies have shown that aspirin, as commonly prescribed drug, prevents the
development of hepatocellular carcinoma (HCC). Ferroptosis as a dynamic tumor …

Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma

C Zhang, N Zhu, J Long, H Wu, Y Wang, B Liu… - Acta Pharmacologica …, 2021 - nature.com
Celastrol is a triterpene derived from the traditional Chinese medicine Tripterygium wilfordii
Hook f, which displays potential anticancer activity. In the present study, we investigated the …

Revealing the role of miRNA-489 as a new onco-suppressor factor in different cancers based on pre-clinical and clinical evidence

MDA Paskeh, S Mirzaei, S Orouei, A Zabolian… - International Journal of …, 2021 - Elsevier
Recently, microRNAs (miRNAs) have shown to be potential therapeutic, diagnostic and
prognostic targets in disease therapy. These endogenous non-coding RNAs contribute to …

The implications of FASN in immune cell biology and related diseases

Y Xiao, Y Yang, H Xiong, G Dong - Cell Death & Disease, 2024 - nature.com
Fatty acid metabolism, particularly fatty acid synthesis, is a very important cellular
physiological process in which nutrients are used for energy storage and biofilm synthesis …

Spatial transcriptomics reveals gene expression characteristics in invasive micropapillary carcinoma of the breast

J Lv, Q Shi, Y Han, W Li, H Liu, J Zhang, C Niu… - Cell Death & …, 2021 - nature.com
Invasive micropapillary carcinoma (IMPC) is a special histological subtype of breast cancer,
featured with extremely high rates of lymphovascular invasion and lymph node metastasis …

Diagnosis of liver cancer by FTIR spectra of serum

X Yang, Q Ou, W Yang, Y Shi, G Liu - Spectrochimica Acta Part A …, 2021 - Elsevier
Liver cancer is the most common fatal malignant tumor in the world. Early diagnosis of liver
cancer can improve the survival rate of the patients with liver disease. In this paper, Fourier …

CircWHSC1 promotes breast cancer progression by regulating the FASN/AMPK/mTOR axis through sponging miR-195-5p

Q Chen, Z Yang, H Ding, H Li, W Wang, Z Pan - Frontiers in Oncology, 2022 - frontiersin.org
Numerous studies reveal that circular RNAs (circRNAs) affect cancer progression.
CircWHSC1 is a novel circRNA that accelerates ovarian cancer progression. Nevertheless …

Diosmetin inhibits cell growth and proliferation by regulating the cell cycle and lipid metabolism pathway in hepatocellular carcinoma

L Pan, F Feng, J Wu, L Li, H Xu, L Yang, K Xu… - Food & Function, 2021 - pubs.rsc.org
Diosmetin (DSM), a newly discovered natural flavonoid, found in citrus plants and olive
leaves, has been reported to inhibit the progression of cancer when used as a food …