Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

A Bonaventura, A Vecchié, L Dagna… - Nature Reviews …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …

COVID-19: the inflammation link and the role of nutrition in potential mitigation

I Zabetakis, R Lordan, C Norton, A Tsoupras - Nutrients, 2020 - mdpi.com
The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has engulfed the world, affecting more than 180 …

Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities

LA Bienvenu, J Noonan, X Wang… - Cardiovascular …, 2020 - academic.oup.com
The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic …

Hypertension, thrombosis, kidney failure, and diabetes: is COVID-19 an endothelial disease? A comprehensive evaluation of clinical and basic evidence

C Sardu, J Gambardella, MB Morelli, X Wang… - Journal of clinical …, 2020 - mdpi.com
The symptoms most commonly reported by patients affected by coronavirus disease (COVID-
19) include cough, fever, and shortness of breath. However, other major events usually …

COVID-19 and cardiac injury: clinical manifestations, biomarkers, mechanisms, diagnosis, treatment, and follow up

A Tajbakhsh, SM Gheibi Hayat… - Expert review of anti …, 2021 - Taylor & Francis
ABSTRACT Introduction Coronavirus disease 2019 (COVID-19) has the characteristics of
high transmission, diverse clinical manifestations, and a long incubation period. In addition …

[HTML][HTML] Expression of SARS-CoV-2 entry factors in the pancreas of normal organ donors and individuals with COVID-19

I Kusmartseva, W Wu, F Syed, V Van Der Heide… - Cell metabolism, 2020 - cell.com
Diabetes is associated with increased mortality from severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2). Given literature suggesting a potential association between …

[HTML][HTML] The long history of vitamin C: from prevention of the common cold to potential aid in the treatment of COVID-19

G Cerullo, M Negro, M Parimbelli, M Pecoraro… - Frontiers in …, 2020 - frontiersin.org
From Pauling's theories to the present, considerable understanding has been acquired of
both the physiological role of vitamin C and of the impact of vitamin C supplementation on …

The SARS-CoV-2 receptor, ACE-2, is expressed on many different cell types: implications for ACE-inhibitor-and angiotensin II receptor blocker-based cardiovascular …

A Albini, G Di Guardo, DMC Noonan… - Internal and emergency …, 2020 - Springer
SARS-CoV-2 is characterized by a spike protein allowing viral binding to the angiotensin-
converting enzyme (ACE)-2, which acts as a viral receptor and is expressed on the surface …

The two faces of ACE2: the role of ACE2 receptor and its polymorphisms in hypertension and COVID-19

M Bosso, TA Thanaraj, M Abu-Farha… - … Therapy Methods & …, 2020 - cell.com
The mechanism for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection requires the binding of the virus to the angiotensin-converting enzyme 2 (ACE2) …

Effective immune functions of micronutrients against SARS-CoV-2

K Junaid, H Ejaz, AE Abdalla, KOA Abosalif, MI Ullah… - Nutrients, 2020 - mdpi.com
The third coronavirus outbreak in the last two decades has caused significant damage to the
world's economy and community health. The highly contagious COVID-19 infection has …