Superoxide, O2•−, is formed in all living organisms that come in contact with air, and,
depending upon its biological context, it may act as a signaling agent, a toxic species, or a …

Superoxide dismutases (SODs) catalyze the de toxification of superoxide. SODs therefore
acquired great importance as O2 became prevalent following the evolution of oxygenic …

The discovery of superoxide dismutases (SODs), which convert superoxide radicals to
molecular oxygen and hydrogen peroxide, has been termed the most important discovery of …

Zinc is known to be indispensable to growth and development and transmission of the
genetic message. It does this through a remarkable mosaic of zinc binding motifs that …

The earliest of a series of copper efflux genes in Escherichia coli are controlled by CueR, a
member of the MerR family of transcriptional activators. Thermodynamic calibration of CueR …

The field of free radical biology originated with the discovery of superoxide dismutase (SOD)
in 1969. Over the last 5 decades, a plethora of research has been performed in species …

Immobilised metal affinity chromatography (IMAC) is the most widely used technique for
single-step purification of recombinant proteins. However, despite its use in the purification …

This Handbook on Metalloproteins focuses on the available structural information of proteins
and their metal ion coordination spheres. It centers on the metal ions indispensable for life …

Scores calculated from intermolecular contacts of proteins in the crystalline state are used to
differentiate monomeric and homodimeric proteins, by classification into two categories …

To bind at an enzyme's active site, a ligand must diffuse or be transported to the enzyme's
surface, and, if the binding site is buried, the ligand must diffuse through the protein to reach …