The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to the ATP
binding cassette (ABC) transporter superfamily but functions as an anion channel crucial for …

Quinoxalinones are a class of heterocyclic compounds which attract extensive attention
owing to their potential in the field of organic synthesis and medicinal chemistry. During the …

Cyclic nucleotide elevation in intestinal epithelial cells is the key pathology causing
intestinal fluid loss in secretory diarrheas such as cholera. Current secretory diarrhea …

Chloride transport across cell membranes is broadly involved in epithelial fluid transport, cell
volume and pH regulation, muscle contraction, membrane excitability, and organellar …

Nephrolithiasis is a common and recurrent disease affecting 9% of the US population.
Hyperoxaluria is major risk factor for calcium oxalate kidney stones, which constitute two …

The anion exchanger protein SLC26A3 (down-regulated in adenoma, DRA) is expressed in
the luminal membrane of intestinal epithelial cells in colon, where it facilitates the absorption …

SLC26A3 (downregulated in adenoma; DRA) is a Cl–/anion exchanger expressed in the
luminal membrane of intestinal epithelial cells, where it facilitates electroneutral NaCl …

We disclose the synthesis of 3-arylquinoxalin-2-ones from o-phenylenediamines and readily
available arylacetates. The method harnesses the selective oxidative property of elemental …

We previously identified phenylquinoxalinone CFTRact-J027 (4) as a cystic fibrosis
transmembrane conductance regulator (CFTR) activator with an EC50 of∼ 200 nM and …

SLC26A6 (also known as putative anion transporter 1 [PAT1]) is a Cl–/HCO 3–exchanger
expressed at the luminal membrane of enterocytes where it facilitates intestinal Cl–and fluid …