Already in the early 1960s, researchers noted the potential of mitochondria to take up large
amounts of Ca2+. However, the physiological role and the molecular identity of the …

In many cell types, IP3 and ryanodine receptor (IP3R/RyR)-mediated Ca2+ mobilization from
the sarcoendoplasmic reticulum (ER/SR) results in an elevation of mitochondrial matrix …

The mitochondrial outer membrane is not just a barrier but a site of regulation of
mitochondrial function. The VDAC family of proteins are the major pathways for metabolite …

Although functional coupling between protein kinase Cε (PKCε) and mitochondria has been
implicated in the genesis of cardioprotection, the signal transduction mechanisms that …

Research on VDAC has accelerated as evidence grows of its importance in mitochondrial
function and in apoptosis. New investigators entering the field are often confounded by the …

Metformin, a drug widely used in the treatment of Type II diabetes, has recently received
attention owing to new findings regarding its mitochondrial and cellular effects. In the …

Mitochondria are the “power house” of a cell continuously generating ATP to ensure its
proper functioning. The constant production of ATP via oxidative phosphorylation demands …

It has become appreciated over the last several years that protein phosphorylation within the
cardiac mitochondrial matrix and respiratory complexes is extensive. Given the importance …

Background: The Voltage Dependent Anion Channel (VDAC) proteins represent the most
important pore-forming proteins of the mitochondrial outer membrane, directly involved in …

The voltage-dependent anion channel (VDAC) or porin is a major membrane protein
integrated into the mitochondrial outer membrane in eukaryotes. It is encoded as three …