Leishmaniasis (visceral and cutaneous), Chagas disease and human African
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …

Pathogenic animal trypanosomes affecting livestock have represented a major constraint to
agricultural development in Africa for centuries, and their negative economic impact is …

Protozoan diseases continue to be a worldwide social and economic health problem.
Increased drug resistance, emerging cross resistance, and lack of new drugs with novel …

With the incidence of sleeping sickness in decline and genuine progress being made
towards the WHO goal of eliminating sleeping sickness as a major public health concern …

Eukaryotic microbial pathogens are major contributors to illness and death globally.
Although much of their impact can be controlled by drug therapy as with prokaryotic …

Arsenicals were introduced as monotherapies for the treatment of human African
trypanosomiasis, or sleeping sickness, over 100 years ago. Toxicity has always been an …

The Cas9 endonuclease can be programmed by guide RNA to introduce sequence-specific
breaks in genomic DNA. Thus, Cas9-based approaches present a range of novel options for …

Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic
functions, including protein degradation, nucleic acid modification, and many others. Given …

Neglected Tropical Diseases (NTD) represent a serious threat to humans, especially for
those living in poor or developing countries. Almost one-sixth of the world population is at …

Profiling of extracts from twelve propolis samples collected from eight regions in Nigeria was
carried out using high performance liquid chromatography (LC) coupled with evaporative …