Triple-negative breast cancer (TNBC) is a special subtype of breast cancer, accounting for
10–20% of breast cancers with high intrinsic heterogeneity. Its unique immune …

Background Besides featured glucose consumption, recent studies reveal that cancer cells
might prefer “addicting” specific energy substrates from the tumor microenvironment (TME); …

With the development of microfluidic technology, tumor-on-chip models have gradually
become a new tool for the study of breast cancer because they can simulate more key …

Background: Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant subtype of
cholangiocarcinoma (CCA) with poor prognosis. In iCCA, the interplay between the stroma …

Background. With the acceleration of the pace of life and work, the incidence rate of invasive
breast cancer is getting higher and higher, and early diagnosis is very important. This study …

Background Exosomes released from cancer cells can activate normal fibroblasts (NFs) into
cancer-associated fibroblasts (CAFs), which promotes cancer development. Our study aims …

IP-10 (also called CXCL10) plays a significant role in leukocyte homing to inflamed tissues,
and increased IP-10 levels are associated with the pathologies of various inflammatory …

Background Increasingly patients with unilateral breast cancer elect to undergo bilateral
mastectomy with subsequent reconstruction. Studies have aimed to better identify the risks …

Thesis Summary Breast cancer is the most frequently diagnosed cancer in women in the UK.
It is a heterogenous disease with subtypes which behave differently. Although several …