Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …

Telomerase is a key enzyme for cell survival that prevents telomere shortening and the
subsequent cellular senescence that is observed after many rounds of cell division. In …

Thyroid cancer (TC) is the eighth most frequently diagnosed cancer worldwide with a rising
incidence in the past 20 years. Surgery is the primary strategy of therapy for patients with …

Telomeres are located at the ends of chromosomes and protect them from degradation.
Suppressing the activity of telomerase, a telomere‑synthesizing enzyme, and maintaining …

Development of precision medicine for malignant pleural mesothelioma (MPM) requires a
deep knowledge of tumor heterogeneity. Histologic and molecular classifications and histo …

Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere
shortening, an inevitable process due to successive cell divisions. In most tumour cells …

Breast cancer is a sporadic disease with genetic and epigenetic components. Genomic
instability in breast cancer leads to mutations, copy number variations, and genetic …

Mutations in the promoter of human telomerase reverse transcriptase (hTERT) result in
hyperactivation of hTERT. Notably, all mutations are G> A transitions, frequently found in a …

Renal cell carcinoma (RCC) consists of the most lethal common urological cancer and the
clinical practice has shown that resistant RCC to commons therapies is extremely high …

Telomerase reverse transcriptase (TERT) gene aberration is detectable in> 80% of cases
with hepatocellular carcinoma (HCC). TERT reactivation is essential for cellular …