ROLE OF LYMPHOCYTE ADHESION RECEPTORS IN TRANSIENT INTERACTIONS AND CELL
LOCOMOTION Page 1 Annu. Rev. Immunol. 1991.9.’27~66 Copyright © 1991 by Annual …

The studies reviewed here exploit the fact that the TCR is a multisubunit complex whose
perturbation initiates an assortment of biochemical pathways and diverse biological …

The CD28 homodimer is thought to function as a signal transducing receptor during
activation of T cells. Evidence is presented that the degree of aggregation of CD28 on the …

The rearrangement of TCR genes during thymic ontogeny creates a repertoire of T cell
specificities that is refined to ensure the deletion of autoreactive clones and the MHC …

Downregulation of the TCR complex is believed to be intimately tied to T cell activation,
allowing serial triggering of receptors and desensitization of stimulated cells. We studied …

NATURAL killer (NK) cells are large granular lymphocytes capable of killing tumour cells in
a non-MHC restricted manner1, 2. NK cells do not express cell-surface CD3, or any known …

We have identified a dominant fetal thymocyte population at day 14.5 of gestation in the
mouse that lacks CD4 and CD8 but expresses FcγRIIIII several days prior to acquisition of …

Publisher Summary This chapter reviews the state of the art in the area of T lymphocyte
signal transduction. The chapter presents a critical overview and synthesis of the important …

Accessory cell surface molecules, such as T cell antigen CD2 and its ligand lymphocyte
function-associated antigen 3 (LFA-3; CD58), are critical costimulatory pathways for optimal …

Chimeric antigen receptors (CARs) can mediate redirected lysis of tumour cells in a major
histocompatibility complex (MHC)-independent manner, thereby enabling autologous …