MRI in traumatic spinal cord injury: from clinical assessment to neuroimaging biomarkers

P Freund, M Seif, N Weiskopf, K Friston… - The Lancet …, 2019 - thelancet.com
Traumatic spinal cord injury occurs when an external physical impact damages the spinal
cord and leads to permanent neurological dysfunction and disability, and it is associated …

Dementia, depression, and associated brain inflammatory mechanisms after spinal cord injury

Y Li, T Cao, RM Ritzel, J He, AI Faden, J Wu - Cells, 2020 - mdpi.com
Evaluation of the chronic effects of spinal cord injury (SCI) has long focused on sensorimotor
deficits, neuropathic pain, bladder/bowel dysfunction, loss of sexual function, and emotional …

Pathophysiology, classification and comorbidities after traumatic spinal cord injury

J Guest, N Datta, G Jimsheleishvili… - Journal of personalized …, 2022 - mdpi.com
The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing
communication between the brain and the rest of the body, conveying complex sensory and …

Efficacy of ultra-early (< 12 h), early (12–24 h), and late (> 24–138.5 h) surgery with magnetic resonance imaging-confirmed decompression in American Spinal Injury …

B Aarabi, N Akhtar-Danesh, T Chryssikos… - Journal of …, 2020 - liebertpub.com
In cervical traumatic spinal cord injury (TSCI), the therapeutic effect of timing of surgery on
neurological recovery remains uncertain. Additionally, the relationship between extent of …

Guidelines for the conduct of clinical trials in spinal cord injury: Neuroimaging biomarkers

M Seif, CAM Gandini Wheeler-Kingshott… - Spinal Cord, 2019 - nature.com
Traumatic spinal cord injury (SCI) leads to immediate neuronal and axonal damage at the
focal injury site and triggers secondary pathologic series of events resulting in sensorimotor …

[HTML][HTML] Myokines may target accelerated cognitive aging in people with spinal cord injury: A systematic and topical review

WAJ Vints, O Levin, N Masiulis, J Verbunt… - Neuroscience & …, 2023 - Elsevier
Persons with spinal cord injury (SCI) can suffer accelerated cognitive aging, even when
correcting for mood and concomitant traumatic brain injury. Studies in healthy older adults …

Role of NLRP3 Inflammasome in post-spinal-cord-injury anxiety and depression: molecular mechanisms and therapeutic implications

T Mokhtari, K Uludag - ACS Chemical Neuroscience, 2023 - ACS Publications
The majority of research on the long-term effects of spinal cord injury (SCI) has primarily
focused on neuropathic pain (NP), psychological issues, and sensorimotor impairments …

[HTML][HTML] Quantitative MRI of rostral spinal cord and brain regions is predictive of functional recovery in acute spinal cord injury

M Seif, A Curt, AJ Thompson, P Grabher, N Weiskopf… - NeuroImage: Clinical, 2018 - Elsevier
Objective To reveal the immediate extent of trauma-induced neurodegenerative changes
rostral to the level of lesion and determine the predictive clinical value of quantitative MRI …

Longitudinal changes of spinal cord grey and white matter following spinal cord injury

G David, D Pfyffer, K Vallotton, N Pfender… - Journal of Neurology …, 2021 - jnnp.bmj.com
Objectives Traumatic and non-traumatic spinal cord injury produce neurodegeneration
across the entire neuraxis. However, the spatiotemporal dynamics of spinal cord grey and …

Brain morphology changes after spinal cord injury: a voxel-based meta-analysis

H Yu, D Chen, H Jiang, G Fu, Y Yang, Z Deng… - Frontiers in …, 2022 - frontiersin.org
Objectives Spinal cord injury (SCI) remodels the brain structure and alters brain function. To
identify specific changes in brain gray matter volume (GMV) and white matter volume (WMV) …