In the last two decades, the amyloid hypothesis, ie, the abnormal accumulation of toxic Aβ
assemblies in the brain, has been considered the mainstream concept sustaining research …

Alzheimer's Diseases (AD) is characterized by the accumulation of amyloid deposits of Aβ
peptide in the brain. Besides genetic background, the presence of other diseases and an …

The development and applications of detergent-free membrane mimetics have been the
focus for the high-resolution structural and functional studies on membrane proteins. The …

Our knowledge of the molecular events underlying type 2 diabetes mellitus—a protein
conformational disease characterized by the aggregation of islet amyloid polypeptide (IAPP) …

Aggregation and the formation of oligomeric intermediates of amyloid-β (Aβ) at the
membrane interface of neuronal cells are implicated in the cellular toxicity and pathology of …

Type 2 Diabetes is a major public health threat, and its prevalence is increasing worldwide.
The abnormal accumulation of islet amyloid polypeptide (IAPP) in pancreatic β-cells is …

The largest part of tau secreted from AD nerve terminals and released in cerebral spinal fluid
(CSF) is C-terminally truncated, soluble and unaggregated supporting potential extracellular …

Graphene oxide (GO) is a bidimensional novel material that exhibits high biocompatibility
and angiogenic properties, mostly related to the intracellular formation of reactive oxygen …

Protein aggregation and amyloid formation are pathogenic events underlying the
development of an increasingly large number of human diseases named “proteinopathies” …

The review describes the stability and the coordination modes of Cu2+ complexes with
different regions of N-terminus prion proteins. The structural features of the different metal …