Simple Summary The ligands BAFF and APRIL and their cognate receptors are critical for
the differentiation, survival, and function of B cells and, as such, the maintenance of humoral …

Nuclear factor-κB (NF-κB) transcription factors play a key role in the pathogenesis of multiple
myeloma (MM). The survival, proliferation and chemoresistance of malignant plasma cells …

Objective Dysregulated APRIL/BAFF signaling is implicated in the pathogenesis of multiple
autoimmune diseases, including systemic lupus erythematosus and lupus nephritis. We …

B-cell activating factor belonging to the TNF family (BAFF), also known as B-lymphocyte
stimulator (BLyS), plays a crucial role in B-cell development. It has multiple receptors …

Multiple myeloma is a hematological neoplasm derived from plasma cells invariably
developing in the bone marrow (BM). The persisting clinical challenge in MM resides in its …

Abstract Purpose Despite BAFF's (B cell activating factor, BAFF) known influence on B cell
survival and proliferation, its specific effects within the tumor microenvironment remain …

The humoral response is frequently dysfunctioning in autoimmunity with a frequent rise in
total serum immunoglobulins, among which are found autoantibodies that may be …

Hormone perception and signaling pathways play a fundamental regulatory function in cell
growth, developmental, and physiological processes in both plant and animal systems …

Decoy receptors form a distinct class of targeted therapeutics that offer unique advantages
compared to traditional antibody therapy. Since they are derived from preexisting signaling …

Множественная миелома остается сложным гематологическим заболеванием,
требующим постоянного изучения его биологии и поиска новых терапевтических …