Proteases are an expanding class of drugs that hold great promise. The US FDA (Food and
Drug Administration) has approved 12 protease therapies, and a number of next generation …

Protein C is a vitamin K-dependent anticoagulant serine protease zymogen in plasma which
upon activation by the thrombin-thrombomodulin complex down-regulates the coagulation …

Thermostabilizing an enzyme while maintaining its activity for industrial or biomedical
applications can be difficult with traditional selection methods. We describe a rapid …

Activated protein C (APC), the only FDA-approved biotherapeutic drug for sepsis, possesses
anticoagulant, antiinflammatory, and barrier-protective activities. However, the mechanisms …

Endothelial protein C receptor (EPCR) and thrombomodulin (TM) are expressed at high
levels in the resting microvasculature and convert protein C (PC) into its activated form …

The direct cytoprotective activities of activated protein C (APC) on cells convey therapeutic,
relevant, beneficial effects in injury and disease models in vivo and require the endothelial …

Activated protein C (APC) is a natural anticoagulant that plays an important role in
coagulation homeostasis by inactivating the procoagulation factor Va and VIIIa. In addition to …

[Frontiers in Bioscience 11, 2381-2399, September 1, 2006] 2381 Protein C anticoagulant
activity in relation to anti-inflammator Page 1 [Frontiers in Bioscience 11, 2381-2399, September …

The purpose of the present study was to assess the therapeutic effect of hypothermic
retrograde jugular vein flush (HRJVF) on heatstroke. HRJVF was accomplished by infusion …

Over the lifespan of therapeutic proteins, from the point of biosynthesis to the complete
clearance from tested subjects, they undergo various biological modifications. Therapeutic …