[HTML][HTML] Phage therapy in the resistance era: where do we stand and where are we going?

T Luong, AC Salabarria, DR Roach - Clinical therapeutics, 2020 - Elsevier
Purpose Widespread antibiotic-resistant bacteria are threatening the arsenal of existing
antibiotics. Not only are antibiotics less likely to be effective today, but their extensive use …

Clostridioides difficile phage biology and application

J Heuler, LC Fortier, X Sun - FEMS Microbiology Reviews, 2021 - academic.oup.com
Clostridium difficile, now reclassified as Clostridioides difficile, is the causative agent of C.
difficile infections (CDI). CDI is particularly challenging in healthcare settings because highly …

PhageTerm: a tool for fast and accurate determination of phage termini and packaging mechanism using next-generation sequencing data

JR Garneau, F Depardieu, LC Fortier, D Bikard… - Scientific reports, 2017 - nature.com
The worrying rise of antibiotic resistance in pathogenic bacteria is leading to a renewed
interest in bacteriophages as a treatment option. Novel sequencing technologies enable …

In vitro characteristics of phages to guide 'real life'phage therapy suitability

E Casey, D Van Sinderen, J Mahony - Viruses, 2018 - mdpi.com
The increasing problem of antibiotic-resistant pathogens has put enormous pressure on
healthcare providers to reduce the application of antibiotics and to identify alternative …

Biological challenges of phage therapy and proposed solutions: a literature review

KM Caflisch, GA Suh, R Patel - Expert review of anti-infective …, 2019 - Taylor & Francis
Introduction: In light of the emergence of antibiotic-resistant bacteria, phage (bacteriophage)
therapy has been recognized as a potential alternative or addition to antibiotics in Western …

Emerging applications of phage therapy and fecal virome transplantation for treatment of Clostridioides difficile infection: challenges and perspectives

H Raeisi, M Noori, M Azimirad, SR Mohebbi… - Gut Pathogens, 2023 - Springer
Clostridioides difficile, which causes life-threatening diarrheal disease, is considered an
urgent threat to healthcare setting worldwide. The current standards of care solely rely on …

Microencapsulation of Clostridium difficile specific bacteriophages using microfluidic glass capillary devices for colon delivery using pH triggered release

GK Vinner, GT Vladisavljević, MRJ Clokie, DJ Malik - PLoS One, 2017 - journals.plos.org
The prevalence of pathogenic bacteria acquiring multidrug antibiotic resistance is a global
health threat to mankind. This has motivated a renewed interest in developing alternatives to …

Phage therapy for Clostridioides difficile infection

K Fujimoto, S Uematsu - Frontiers in immunology, 2022 - frontiersin.org
Clostridioides difficile is endemic in the intestinal tract of healthy people. However, it is
responsible for many healthcare-associated infections, such as nosocomial diarrhea …

Bacteriophage endolysins as a potential weapon to combat Clostridioides difficile infection

SI Mondal, LA Draper, RP Ross, C Hill - Gut Microbes, 2020 - Taylor & Francis
Clostridioides difficile is the leading cause of health-care-associated infection throughout the
developed world and contributes significantly to patient morbidity and mortality. Typically …

[HTML][HTML] Isolation and characterization of new bacteriophages active against Clostridium tyrobutyricum and their role in preventing the late blowing defect of cheese

M Ávila, C Sánchez, J Calzada, MJ Mayer… - Food Research …, 2023 - Elsevier
Lytic bacteriophages (phages) offer a great potential as biocontrol agents for spoilage
Clostridium tyrobutyricum, responsible for butyric acid fermentation in semi-hard and hard …