The mechanisms that explain mitochondrial dysfunction in aging and healthspan continue to
be studied, but one element has been unexplored: microproteins. Small open reading …

Mitochondrial-derived peptides (MDPs) are small bioactive peptides encoded by short open-
reading frames (sORF) in mitochondrial DNA that do not necessarily have traditional …

Mitochondrial diabetes (MD) is generally classified as a genetic defect of β-cells. The main
pathophysiology is insulin secretion failure in pancreatic β-cells due to impaired …

MOTS-c is a peptide encoded by the short open reading frame of the mitochondrial 12S
rRNA gene. It is significantly expressed in response to stress or exercise and translocated to …

Mitochondrial DNA variants have previously associated with disease, but the underlying
mechanisms have been largely elusive. Here, we report that mitochondrial SNP rs2853499 …

Mitochondria are principal metabolic organelles that are increasingly unveiled as immune
regulators. However, it is currently not known whether mitochondrial-encoded peptides …

MOTS-c, a 16 amino acid mitochondrial derived peptide, is encoded from the 12S rRNA
region of the mitochondrial genome. Under stress conditions, MOTS-c translocates to the …

A decline in mitochondrial quality and activity has been associated with normal aging and
correlated with the development of a wide range of age-related diseases. Here, we review …

For many years, it was believed that the aging process was inevitable and that age‐related
diseases could not be prevented or reversed. The geroscience hypothesis, however, posits …

MOTS-c is a mitochondrial derived peptide with exercise mimetic activity that elicits
beneficial effects on metabolism and exercise capacity. Furthermore, MOTS-c effects in …