More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitin–
proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors …

The ubiquitin proteasome system maintains protein homeostasis by regulating the
breakdown of misfolded proteins, thereby preventing misfolded protein aggregates. The …

Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated
with proteasomes and exerts a dual function in regulating protein degradation. USP14 …

Ubiquitylation is a major posttranslational modification that controls most complex aspects of
cell physiology. It is reversed through the action of a large family of deubiquitylating …

Proteasomes, the primary mediators of ubiquitin–protein conjugate degradation, are
regulated through complex and poorly understood mechanisms. Here we show that USP14 …

Deubiquitinating enzymes (DUBs) are proteases that process ubiquitin or ubiquitin-like gene
products, reverse the modification of proteins by a single ubiquitin (-like) protein, and …

The proper regulation of apoptosis is essential for the survival of multicellular organisms.
Furthermore, excessive apoptosis can contribute to neurodegenerative diseases, anaemia …

Purpose The management of epilepsy in children is particularly challenging when seizures
are resistant to antiepileptic medications, or undergo many changes in seizure type over …

UCHL1/PGP 9.5 (also known as UCHL1 and PGP 9.5) was first detected as a “brain-specific
protein” over 28 years ago. The protein is highly conserved and localized in neurones and …

Abstract Three deubiquitinating enzymes—Rpn11, Usp14, and Uch37—are associated with
the proteasome regulatory particle. These enzymes allow proteasomes to remove ubiquitin …