The past 2 decades have seen a revolution in our approach to therapeutic
immunosuppression. We have moved from relying on broadly active traditional medications …

In the era of COVID-19, understanding how our immune system responds to viral infections
is more pertinent than ever. Immunodeficiencies with very low or absent B cells offer a …

Objective Rituximab, a monoclonal antibody specifically targeting CD20, induces B cell
depletion and is effective in the treatment of rheumatoid arthritis (RA). This study was …

Regulatory T cells (Tregs) and B cells present in gut-associated lymphoid tissues (GALT) are
both implicated in the resolution of colitis. However, how the functions of these cells are …

The importance of the gastrointestinal (GI) tract in development of autoimmunity has been
increasingly appreciated in human diseases. 1, 2 Many autoimmune diseases primarily …

Multiple sclerosis (MS) and inflammatory bowel disease (IBD) are autoimmune disorders
characterized by inflammatory episodes affecting the brain and the gastrointestinal (GI) tract …

Rituximab (RTX) is a chimeric monoclonal antibody that targets the CD20 antigen on B cells
and is used in various autoimmune disorders. In this study, we aimed to measure the …

B-cell depletion therapy based on rituximab is effective and relatively safe in established
rheumatoid arthritis. Rituximab is licensed for the treatment of rheumatoid arthritis in …

Background Focal segmental glomerulosclerosis (FSGS) recurs in 20–40% of allografts.
Plasmapheresis (TPE) has been one of the mainstays of treatment with variable results …

Rituximab (RTX) in combination with glucocorticoids has been recommended for relapsing
granulomatosis with polyangiitis (GPA) if the disease remains active after a course of …