Human APOBEC3 variations and viral infection
S Sadeghpour, S Khodaee, M Rahnama, H Rahimi… - Viruses, 2021 - mdpi.com
Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes
are capable of inhibiting a wide range of endogenous and exogenous viruses using …
are capable of inhibiting a wide range of endogenous and exogenous viruses using …
The role of APOBECs in viral replication
WK Xu, H Byun, JP Dudley - Microorganisms, 2020 - mdpi.com
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) proteins are a
diverse and evolutionarily conserved family of cytidine deaminases that provide a variety of …
diverse and evolutionarily conserved family of cytidine deaminases that provide a variety of …
APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection
L Manjunath, S Oh, P Ortega, A Bouin… - Nature …, 2023 - nature.com
Double-stranded RNA produced during viral replication and transcription activates both
protein kinase R (PKR) and ribonuclease L (RNase L), which limits viral gene expression …
protein kinase R (PKR) and ribonuclease L (RNase L), which limits viral gene expression …
Mechanistic insight into antiretroviral potency of 2′-deoxy-2′-β-fluoro-4′-azidocytidine (FNC) with a long-lasting effect on HIV-1 prevention
L Sun, Y Peng, W Yu, Y Zhang, L Liang… - Journal of Medicinal …, 2020 - ACS Publications
In preclinical and phase I and II clinical studies, 2′-deoxy-2′-β-fluoro-4′-azidocytidine
(FNC) displays a potent and long-lasting inhibition of HIV-1 infection. To investigate its …
(FNC) displays a potent and long-lasting inhibition of HIV-1 infection. To investigate its …
APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1
ABSTRACT HIV-1 must overcome multiple innate antiviral mechanisms to replicate in CD4+
T lymphocytes and macrophages. Previous studies have demonstrated that the …
T lymphocytes and macrophages. Previous studies have demonstrated that the …
Dendritic cells, the double agent in the war against HIV-1
A Martín-Moreno, MA Muñoz-Fernández - Frontiers in immunology, 2019 - frontiersin.org
Human Immunodeficiency Virus (HIV) infects cells from the immune system and has thus
developed tools to circumvent the host immunity and use it in its advance. Dendritic cells …
developed tools to circumvent the host immunity and use it in its advance. Dendritic cells …
Examination of the APOBEC3 barrier to cross species transmission of primate lentiviruses
The transmission of viruses from animal hosts into humans have led to the emergence of
several diseases. Usually these cross-species transmissions are blocked by host restriction …
several diseases. Usually these cross-species transmissions are blocked by host restriction …
Structural insights into APOBEC3-mediated lentiviral restriction
KA Delviks-Frankenberry, BA Desimmie, VK Pathak - Viruses, 2020 - mdpi.com
Mammals have developed clever adaptive and innate immune defense mechanisms to
protect against invading bacterial and viral pathogens. Human innate immunity is …
protect against invading bacterial and viral pathogens. Human innate immunity is …
Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization
Abstract The seven APOBEC3 (A3) enzymes in primates restrict HIV/SIV replication to
differing degrees by deaminating cytosine in viral (−) DNA, which forms promutagenic …
differing degrees by deaminating cytosine in viral (−) DNA, which forms promutagenic …
Biochemical basis of APOBEC3 deoxycytidine deaminase activity on diverse DNA substrates
The Apolipoprotein B mRNA editing complex (APOBEC) family of enzymes contains single-
stranded polynucleotide cytidine deaminases. These enzymes catalyze the deamination of …
stranded polynucleotide cytidine deaminases. These enzymes catalyze the deamination of …