CD28 costimulation regulates a wide range of cellular processes, from proliferation and
survival to promoting the differentiation of specialized T-cell subsets. Since first being …

HIV-1 can infect both activated and resting, non-dividing cells, following which the viral
genome can be permanently integrated into a host cell chromosome. Latent HIV-1 reservoirs …

The dsRNA binding proteins (DRBPs) comprise a growing family of eukaryotic, prokaryotic,
and viral‐encoded products that share a common evolutionarily conserved motif specifically …

PG490 (triptolide) is a diterpene triepoxide with potent immunosuppressive and
antiinflammatory properties. PG490 inhibits interleukin (IL)-2 expression by normal human …

Highly structured and double-stranded (ds) RNAs are adaptable and potent biochemical
entities. They interact with dsRNA-binding proteins (RBPs), the great majority of which …

Interleukin-2 (IL-2), the cytokine also known as T-cell growth factor, has multiple
immunoregulatory functions and biological properties not only related to T-cells. In the past …

Arginine methylation is a common post-translation modification found in many proteins.
Protein-arginine methyltransferase I (PRMT1) contributes> 90% of type I protein-arginine …

Double‐stranded RNA‐binding proteins (DRBPs) are known to regulate many processes of
RNA metabolism due, among others, to the presence of double‐stranded RNA (dsRNA) …

Nuclear Factor of Activated T-cells (NF-AT) is a crucial transcription factor required for T-cell
expression of interleukin 2. Purified NF-AT contains 45-kDa and 90-kDa subunits (Corthésy …

The secretion of the T cell growth factor Interleukin 2 (IL-2) is a key event in the activation of
T lymphocytes. IL-2 triggers peripheral T lymphocytes to enter the S phase of the cell cycle …