Stress influences circulating inflammatory markers, and these effects may mediate the
influence of psychosocial factors on cardiovascular risk and other conditions such as …

Abstract Turnbull, Andrew V., and Catherine L. Rivier. Regulation of the Hypothalamic-
Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action. Physiol. Rev. 79: 1 …

I. Introduction THE existence of mechanisms that provide immunity to an infective agent was
inferred from empirical observations obtained through the ingenuity and deductive capacity …

In this chapter we argue that a variety of behavioral, affective, and cognitive phenomena are
driven by events in the immune system. These events occur in response to infection, injury …

Recently, the inflammatory and neurodegenerative (I&ND) hypothesis of depression was
formulated (Maes et al., 2009), ie the neurodegeneration and reduced neurogenesis that …

Contemporary models of major depression emphasize the role of hypothalamic-pituitary-
adrenal (HPA)-axis hyperactivity and of dysfunctions in the turnover of serotonin (5-HT) or …

Prior exposure to a stressor can potentiate CNS pro-inflammatory immune responses to a
peripheral immune challenge. However, the neuroimmune substrate (s) mediating this effect …

The brain is not only immunologically active of its own accord, but also has complex
peripheral immune interactions. Given the central role of cytokines in …

It has recently become accepted that the activated immune system communicates to brain
via release of pro-inflammatory cytokines. This review examines the possibility that pro …

There is now evidence that depression, as characterized by melancholic symptoms, anxiety,
and fatigue and somatic (F&S) symptoms, is the clinical expression of peripheral cell …