The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes
develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin …

Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …

Recent advances in human pluripotent stem cell (hPSC) differentiation protocols have
generated insulin-producing cells resembling pancreatic β cells. While these stem cell …

Stem-cell-based therapies can potentially reverse organ dysfunction and diseases, but the
removal of impaired tissue and activation of a program leading to organ regeneration pose …

We recently reported the scalable in vitro production of functional stem cell-derived β-cells
(SC-β cells). Here we extend this approach to generate the first SC-β cells from type 1 …

Like all the cells of an organism, pancreatic β-cells originate from embryonic stem cells
through a complex cellular process termed differentiation. Differentiation involves the …

Postnatal maintenance or regeneration of pancreatic beta cells is considered to occur
exclusively via the replication of existing beta cells, but clinically meaningful restoration of …

It is well known that type 2 diabetes mellitus (T2D) is a globally increasing health burden.
Despite recent therapeutic advances and the availability of many different classes of …

The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and
their support cells, which together tightly control blood glucose homeostasis. Changes in …

The reversible nature of early type 2 diabetes has been demonstrated in in vivo human
studies. Recent in vivo and in vitro studies of β-cell biology have established that the β-cell …