Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

[PDF][PDF] The role of hydrogen sulfide in pathologies of the vital organs and its clinical application

Z Jin, H Chan, J Ning, K Lu, D Ma - Journal of Physiology and …, 2015 - jpp.krakow.pl
Hydrogen sulfide (H2S) is one of the more recently recognised gaseous transmitters that
have been shown to be involved in a large range of cellular functions. While H2S generally …

Evaluation of the cardiotoxicity of mitragynine and its analogues using human induced pluripotent stem cell-derived cardiomyocytes

J Lu, H Wei, J Wu, MFA Jamil, ML Tan, MI Adenan… - PloS one, 2014 - journals.plos.org
Introduction Mitragynine is a major bioactive compound of Kratom, which is derived from the
leave extracts of Mitragyna speciosa Korth or Mitragyna speciosa (M. speciosa), a medicinal …

Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases

R Tabassum, NY Jeong, J Jung - Neural Regeneration Research, 2020 - journals.lww.com
Hydrogen sulfide (H 2 S) is a gasotransmitter that acts as an antioxidant and exhibits a wide
variety of cytoprotective and physiological functions in age-associated diseases. One of the …

Cardioprotective Effects of Hydrogen Sulfide and Its Potential Therapeutic Implications in the Amelioration of Duchenne Muscular Dystrophy Cardiomyopathy

A Łoboda, J Dulak - Cells, 2024 - mdpi.com
Hydrogen sulfide (H2S) belongs to the family of gasotransmitters and can modulate a myriad
of biological signaling pathways. Among others, its cardioprotective effects, through …

Hydrogen sulphide suppresses human atrial fibroblast proliferation and transformation to myofibroblasts

J Sheng, W Shim, H Wei, SY Lim, R Liew… - Journal of Cellular …, 2013 - Wiley Online Library
Cardiac fibroblasts are crucial in pathophysiology of the myocardium whereby their aberrant
proliferation has significant impact on cardiac function. Hydrogen sulphide (H2S) is a …

Epigenetic mechanisms in atrial fibrillation: new insights and future directions

H Tao, KH Shi, JJ Yang, J Li - Trends in cardiovascular medicine, 2016 - Elsevier
Atrial fibrillation (AF) is the most common sustained arrhythmia. AF is a complex disease that
results from genetic and environmental factors and their interactions. In recent years …

Hydrogen sulfide augments the proliferation and survival of human induced pluripotent stem cell–derived mesenchymal stromal cells through inhibition of BKCa

Y Zhao, H Wei, G Kong, W Shim, G Zhang - Cytotherapy, 2013 - Elsevier
Abstract Background Hydrogen sulfide (H 2 S) is an endogenously generated gaseous
transmitter known for its cytoprotective effect mediated by the PI3K-Akt signaling pathway …

Possible cardioprotective role of NaHS on ECG and oxidative stress markers in an unpredictable chronic mild stress model in rats

M Ghalwash, A Elmasry… - Canadian Journal of …, 2021 - cdnsciencepub.com
The protective effect of H2S against various body organ injuries has been described. The
aim of this work is to investigate the potential role of sodium hydrosulfide (NaHS) as an H2S …

Hydrogen sulfide inhibits Kir2 and Kir3 channels by decreasing sensitivity to the phospholipid phosphatidylinositol 4, 5-bisphosphate (PIP2)

J Ha, Y Xu, T Kawano, T Hendon, L Baki… - Journal of Biological …, 2018 - ASBMB
Inwardly rectifying potassium (Kir) channels establish and regulate the resting membrane
potential of excitable cells in the heart, brain, and other peripheral tissues …