Energy metabolism is a universal process occurring in all life forms. In Mycobacterium
tuberculosis (Mtb), energy production is carried out in two possible ways, oxidative …

Abstract Alanine dehydrogenase (AlaDH)(EC 1.4. 1.1) is a microbial enzyme that catalyzes
a reversible conversion of L-alanine to pyruvate. Inter-conversion of alanine and pyruvate by …

Developing new, more effective antibiotics against resistant Mycobacterium tuberculosis that
inhibit its essential proteins is an appealing strategy for combating the global tuberculosis …

Tuberculosis caused by the bacterium, Mycobacterium tuberculosis (Mtb), continues to
remain one of the most devastating infectious diseases afflicting humans. Although there are …

Antimicrobial peptides (AMPs), ancient scavengers of bacteria, are very poorly induced in
macrophages infected by Mycobacterium tuberculosis (M. tuberculosis), but the underlying …

Structure-based pharmacophore approaches have become widely used in drug discovery
and design. This can be attributed to the development of new tools and methods over the …

Despite being discovered and isolated more than one hundred years ago, tuberculosis (TB)
remains a global public health concern arch. Our inability to eradicate this bacillus is …

In the present study, we used crystal structure of MTB L-AlaDH protein complex with N 6-
methyl adenosine for structure based virtual screening of in house database to identify new …

The rich indigenous and endemic plants in Taiwan serve as a resourceful bank for
biologically active phytochemicals. Based on our TIPdb database curating bioactive …

Here we demonstrated that the inhibition of electron flux through the respiratory electron
transport chain (ETC) by either the disruption of the gene for the major terminal oxidase (aa …