Cell migration is a highly dynamic process driven by the cytoskeleton, which mainly
comprises the actin microfilaments, microtubules, and intermediate filaments. During …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

Cancer relapse after chemotherapy remains a main cause of cancer-related death. Although
the relapse is thought to result from the propagation of resident cancer stem cells, a lack of …

One of the most important functions of skin is to act as a protective barrier. To fulfill this role,
the structural integrity of the skin depends on the dermal-epidermal junction—a complex …

The skin forms a crucial, dynamic barrier between an animal and the external world. In
mammals, three stem cell populations possess robust regenerative potential to maintain and …

Allergic rhinitis (AR) is a common disorder affecting up to 40% of the population worldwide
and it usually persists throughout life. Nasal epithelial barrier constitutes the first line of …

Physical forces regulate numerous biological processes during development, physiology,
and pathology. Forces between the external environment and intracellular actin cytoskeleton …

The coordinated interplay of cytoskeletal networks critically determines tissue biomechanics
and structural integrity. Here, we show that plectin, a major intermediate filament-based …

Chronic wounds, such as diabetic foot ulcers (DFU), are a serious clinical problem. It is a
challenge for the conventional wound dressings to achieve the desirable therapeutic …

The keratin network of intermediate filaments provides keratinocytes with essential
mechanical strength and resilience, but the contribution to mechanosensing remains poorly …