Population aging is among the most important global transformations. Today, 12% of the
world population is of age 60 and over and by the middle of this century this segment will …

Background The panel of fluid-and imaging-based biomarkers available for
neurodegenerative disease research is growing and has the potential to close important …

Alzheimer's disease (AD) is characterized by the selective vulnerability of specific neuronal
populations, the molecular signatures of which are largely unknown. To identify and …

Introduction Alzheimer's disease (AD) progression follows a specific spreading pattern,
emphasizing the need to characterize those brain areas that degenerate first. The …

The human brain is often considered to be the most cognitively capable among mammalian
brains and to be much larger than expected for a mammal of our body size. Although the …

Dementia is more prevalent in Blacks than in Whites, likely due to a combination of
environmental and biological factors. Paradoxically, clinical studies suggest an attenuation …

Aims Hyperphosphorylated tau neuronal cytoplasmic inclusions (ht‐NCI) are the best
protein correlate of clinical decline in Alzheimer's disease (AD). Qualitative evidence …

Clarifying the relationships between neuropsychiatric symptoms and Alzheimer's disease
(AD)-related pathology may open avenues for effective treatments. Here, we investigate the …

Alzheimer's disease (AD) is a severe neurodegenerative disorder still in search of effective
methods of diagnosis. Altered levels of the NMDA receptor co-agonist, d-serine, have been …

Histopathological studies in Alzheimer's disease (AD) suggest severe and region-specific
neurodegeneration of the basal forebrain cholinergic system (BFCS). Here, we studied the …