Mechanisms of epigenetic regulation, including DNA methylation, chromatin remodeling,
and histone post-translational modifications, are involved in multiple aspects of neuronal …

Neuroepigenetics is a newly emerging field in neurobiology that addresses the epigenetic
mechanism of gene expression regulation in various postmitotic neurons, both over time and …

Brain microvascular endothelial cells (BMECs) are an essential component of the blood-
brain barrier (BBB) that shields the brain against toxins and immune cells. While BBB …

Normal brain function depends on the interaction between highly specialized neurons that
operate within anatomically and functionally distinct brain regions. Neuronal specification is …

Simple Summary DNA methylation is an epigenetic modification of genes which affects
corresponding gene expression. During the developmental stage, embryonic stem cells …

Advances achieved with molecular biology and genomics technologies have permitted
investigators to discover epigenetic mechanisms, such as DNA methylation and histone …

The human brain is a complex organ comprised of distinct cell types, and the contribution of
the 3D genome to lineage specific gene expression remains poorly understood. To decipher …

Large-scale consortia mapping the genomic risk architectures of schizophrenia provide vast
amounts of molecular information, with largely unexplored therapeutic potential. We …

Prion diseases are transmissible spongiform encephalopathies (TSEs) caused by a
conformational conversion of the native cellular prion protein (PrPC) to an abnormal …

Huntington's disease (HD) is a devastating and fatal monogenic neurodegenerative disorder
characterized by progressive loss of selective neurons in the brain and is caused by an …