[HTML][HTML] Designer exosomes: a new platform for biotechnology therapeutics

D Jafari, S Shajari, R Jafari, N Mardi, H Gomari, F Ganji… - BioDrugs, 2020 - Springer
Desirable features of exosomes have made them a suitable manipulative platform for
biomedical applications, including targeted drug delivery, gene therapy, cancer diagnosis …

[HTML][HTML] The therapeutic potential of stem cell-derived exosomes in the ulcerative colitis and colorectal cancer

G Guo, Z Tan, Y Liu, F Shi, J She - Stem cell research & therapy, 2022 - Springer
Abstract Background Mesenchymal stem cells (MSCs) therapy is a novel treatment strategy
for cancer and a wide range of diseases with an excessive immune response such as …

[HTML][HTML] Stem cell-derived and circulating exosomal microRNAs as new potential tools for diabetic nephropathy management

L Peng, Y Chen, S Shi, H Wen - Stem Cell Research & Therapy, 2022 - Springer
Background Despite major advances in the treatment of diabetic nephropathy (DN) in recent
years, it remains the most common cause of end-stage renal disease. An early diagnosis …

Mesenchymal stem cell-derived exosomes carry MicroRNA-125a to protect against diabetic nephropathy by targeting histone deacetylase 1 and downregulating …

Y Hao, J Miao, W Liu, K Cai, X Huang… - … Syndrome and Obesity, 2021 - Taylor & Francis
Background Mesenchymal stem cell (MSC)-derived exosomes have seen great advances in
human disease control in a minimally invasive manner. This research aimed to explore the …

[HTML][HTML] Advancements in engineered exosomes for wound repair: current research and future perspectives

H Ye, F Wang, G Xu, F Shu, K Fan… - … in Bioengineering and …, 2023 - frontiersin.org
Wound healing is a complex and prolonged process that remains a significant challenge in
clinical practice. Exosomes, a type of nanoscale extracellular vesicles naturally secreted by …

Improvement, scaling-up, and downstream analysis of exosome production

D Jafari, S Malih, M Eini, R Jafari… - Critical reviews in …, 2020 - Taylor & Francis
Exosomes are the most researched extracellular vesicles. In many biological, physiological,
and pathological studies, they have been identified as suitable candidates for treatment and …

The secretome of mesenchymal stem cells and oxidative stress: challenges and opportunities in cell-free regenerative medicine

B Rahimi, M Panahi, N Saraygord-Afshari… - Molecular Biology …, 2021 - Springer
Over the last decade, mesenchymal stem cells (MSCs) have been considered a suitable
source for cell-based therapy, especially in regenerative medicine. First, the efficacy and …

[HTML][HTML] The role of mesenchymal stem cells derived exosomes as a novel nanobiotechnology target in the diagnosis and treatment of cancer

Y Zhou, Y Dong, A Zhang, J Wu, Q Sun - Frontiers in Bioengineering …, 2023 - frontiersin.org
Mesenchymal stem cells (MSCs), one of the most common types of stem cells, are involved
in the modulation of the tumor microenvironment (TME). With the advancement of …

[HTML][HTML] Extracellular vesicles: Potential role in osteoarthritis regenerative medicine

X Wu, Y Wang, Y Xiao, R Crawford, X Mao… - Journal of orthopaedic …, 2020 - Elsevier
Osteoarthritis (OA) is a prevalent whole joint disease characterised by cartilage degradation,
subchondral bone sclerosis and bone remodelling, and synovium inflammation, leading to …

Exosomes and nano-SDF scaffold as a cell-free-based treatment strategy improve traumatic brain injury mechanisms by decreasing oxidative stress …

M Hajinejad, MH Ebrahimzadeh… - Stem Cell Reviews and …, 2023 - Springer
Traumatic brain injury (TBI) causes a variety of complex pathological changes in brain
parenchymal tissue by increasing neuroinflammatory and apoptosis responses. Currently …