With its wide distribution in soft and hard connective tissues, collagen is the most abundant
of animal proteins. In vitro, natural collagen can be formed into highly organized, three …

Collagen is the most widely distributed class of proteins in the human body. The use of
collagen-based biomaterials in the field of tissue engineering applications has been …

Corneas from human donors are used to replace damaged tissue and treat corneal
blindness, but there is a severe worldwide shortage of donor corneas. We conducted a …

In recent years, the tissue engineering paradigm has shifted to include a new and growing
subfield of scaffoldless techniques that generate self-organizing and self-assembling …

The advantageous biocompatibility and cell proliferative effects of synthetic and natural
biomaterials have promoted their broad use in various medical areas, including wound …

Corneal blindness is traditionally treated by transplantation of a donor cornea, or in severe
cases by implantation of an artificial cornea or keratoprosthesis. Due to severe donor …

Corneal blindness is a major cause of blindness in the world and corneal transplantation is
the only widely accepted treatment to restore sight in these eyes. However, it is becoming …

Purpose The purpose of this study was to produce and characterize human tissue-
engineered corneas reconstructed using all three corneal cell types (epithelial, stromal, and …

The silk structural protein fibroin displays potential for use in tissue engineering. We present
here our opinion of its value as a biomaterial for reconstructing tissues of clinical …

Each day, about 2000 US workers have a job-related eye injury requiring medical treatment.
Corneal diseases are the fifth cause of blindness worldwide. Most of these diseases can be …