The existence of orderly structures, such as tissues and organs is made possible by cell
adhesion, ie, the process by which cells attach to neighbouring cells and a supporting …

Estrogens are critical mediators of multiple and diverse physiologic effects throughout the
body in both sexes, including the reproductive, cardiovascular, endocrine, nervous, and …

The green fluorescent protein (GFP) and its variants are used in many studies to determine
the subcellular localization of other proteins by analyzing fusion proteins. The main problem …

Orphan nuclear receptors have been instrumental in identifying novel signaling pathways
and therapeutic targets. However, identification of ligands for these receptors has often been …

The corticosteroid receptors (CR) control a vast array of physiological processes acting
primarily as ligand-dependent transcription factors. The origins of the gnathostomata CRs …

Nuclear localization of the androgen receptor (AR) is necessary for its activation as a
transcription factor. Defining the mechanisms regulating AR nuclear localization in androgen …

A bimodal switch model is widely used to describe transcriptional regulation by the thyroid
hormone receptor (TR). In this model, the unliganded TR forms stable, chromatin-bound …

Targeted delivery of nucleic acids into disease sites of human body has been attempted for
decades, but both viral and non-viral vectors are yet to meet our expectations. Safety …

Arrival of multi-colored fluorescent proteins and advances in live cell imaging has
immensely contributed to our understanding of intracellular trafficking of nuclear receptors …

Pharmacological doses of glucocorticoids (GCs), acting via the glucocorticoid receptor (GR)
to repress inflammation and immune function, remain the most effective therapy in the …