Lung cancer is the cardinal cause of cancer-related deaths with restricted recourse of
therapy throughout the world. Clinical success of therapies is not very promising due to-late …

The platinum derivative cis-diamminedichloroplatinum (II), best known as cisplatin, is
currently employed for the clinical management of patients affected by testicular, ovarian …

Inflammation can be either beneficial or detrimental to the liver, depending on multiple
factors. Mild (ie, limited in intensity and destined to resolve) inflammatory responses have …

Antineoplastic chemotherapies are particularly efficient when they elicit immunogenic cell
death, thus provoking an anticancer immune response. Here we demonstrate that …

Cisplatin (CP) is a well-known chemotherapeutic agent with excellent clinical effects. The
anti-tumor activity of CP has been demonstrated in different cancers such as breast, cervical …

In normal cells multiple microRNAs (miRNAs) converge to maintain a proper balance of
various processes, including proliferation, differentiation and cell death. miRNA …

The immunogenic demise of cancer cells can be induced by various chemotherapeutics,
such as anthracyclines and oxaliplatin, and provokes an immune response against tumor …

The term “mitochondrial permeability transition”(MPT) refers to an abrupt increase in the
permeability of the inner mitochondrial membrane to low molecular weight solutes. Due to …

Cell death has an important role in many human diseases, and strategies aimed at
modulating the associated pathways have been successfully applied to treat various …

The term “immunogenic cell death”(ICD) is now employed to indicate a functionally peculiar
form of apoptosis that is sufficient for immunocompetent hosts to mount an adaptive immune …