Mechanisms and pathology of protein misfolding and aggregation

N Louros, J Schymkowitz, F Rousseau - Nature Reviews Molecular Cell …, 2023 - nature.com
Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …

Neuroinflammation in Parkinson's disease–putative pathomechanisms and targets for disease-modification

A Grotemeyer, RL McFleder, J Wu… - Frontiers in …, 2022 - frontiersin.org
Parkinson's disease (PD) is a progressive and debilitating chronic disease that affects more
than six million people worldwide, with rising prevalence. The hallmarks of PD are motor …

SARS-CoV-2 proteins interact with alpha synuclein and induce Lewy body-like pathology in vitro

Z Wu, X Zhang, Z Huang, K Ma - International Journal of Molecular …, 2022 - mdpi.com
Growing cases of patients reported have shown a potential relationship between (severe
acute respiratory syndrome coronavirus 2) SARS-CoV-2 infection and Parkinson's disease …

Links between COVID-19 and Parkinson's disease/Alzheimer's disease: reciprocal impacts, medical care strategies and underlying mechanisms

P Huang, LY Zhang, YY Tan, SD Chen - Translational Neurodegeneration, 2023 - Springer
The impact of coronavirus disease 2019 (COVID-19) pandemic on patients with
neurodegenerative diseases and the specific neurological manifestations of COVID-19 have …

Spike Protein Fragments Promote Alzheimer's Amyloidogenesis

S Cao, Z Song, J Rong, N Andrikopoulos… - … Applied Materials & …, 2023 - ACS Publications
Alzheimer's disease (AD) is a major cause of dementia inducing memory loss, cognitive
decline, and mortality among the aging population. While the amyloid aggregation of …

[HTML][HTML] Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation

W Wang, J Chen, X Yu, HY Lan - International journal of biological …, 2022 - ncbi.nlm.nih.gov
COVID-19 which is caused by severe acute respiratory syndrome coronavirus (SARS-CoV-
2) has posed a worldwide pandemic and a major global public health threat. SARS-CoV-2 …

SARS‐COV‐2 infection and Parkinson's disease: possible links and perspectives

HM Al‐kuraishy, AI Al‐Gareeb… - Journal of …, 2023 - Wiley Online Library
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive
loss of dopaminergic neurons in the substantia nigra. The hallmarks are the presence of …

Intrinsically disordered proteins/regions and insight into their biomolecular interactions

P Chakrabarti, D Chakravarty - Biophysical Chemistry, 2022 - Elsevier
Proteins may vary from being rigid to having flexible regions to being completely disordered,
either as an intrinsically disordered protein (IDP) or having specific intrinsically disordered …

[HTML][HTML] SARS-CoV-2 infection causes dopaminergic neuron senescence

L Yang, TW Kim, Y Han, MS Nair, O Harschnitz, J Zhu… - Cell Stem Cell, 2024 - cell.com
COVID-19 patients commonly present with signs of central nervous system and/or peripheral
nervous system dysfunction. Here, we show that midbrain dopamine (DA) neurons derived …

Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils

E Tayeb-Fligelman, JT Bowler, CE Tai… - Nature …, 2023 - nature.com
The self-assembly of the Nucleocapsid protein (NCAP) of SARS-CoV-2 is crucial for its
function. Computational analysis of the amino acid sequence of NCAP reveals low …