β-Carboline alkaloids are a remarkable family of natural and synthetic indole-containing
heterocyclic compounds and they are widely distributed in nature. Recently, these alkaloids …

Conspectus Polycyclic natural products are an inexhaustible source of medicinal agents,
and their complex molecular architecture renders challenging synthetic targets where …

The divergent synthesis of natural products is rapidly developing towards achieving the goal
of efficiency and economy in total synthesis. However, presently, the sustainable …

Indole is a versatile pharmacophore widely distributed in bioactive natural products. This
privileged scaffold has been found in a variety of molecules isolated from marine organisms …

The first sequential acid-catalyzed propargylation/base-mediated aza-cycloisomerization
between indolyl-benzimidazoles and propargylic alcohols is described. This protocol …

Utilization of Freon-type methanes as functional one-carbon synthons in the synthesis of
various deuterated indoline alkaloids was demonstrated here. A series of halomethyl …

Three new flavipin-derived alkaloids, azacoccones FH (1–3), along with six known
compounds (4–9) were isolated from the endophytic fungus Epicoccum nigrum MK214079 …

Axially chiral atropisomers have energetic barriers to rotation, Δ G rot, that prevent
racemization of the respective enantiomers. We used computational modeling to develop a …

One-pot synthesis of tetrahydro-β-carbolines, fused with an isoindole core, was proposed
starting from maleic anhydride and azomethines easily available from tryptamines and 3 …

Lyoniresinol and its derivatives are lignans which have been isolated from a plethora of
plant species. In addition to exhibiting a range of interesting biological activities including …