Cancer is a multistep disease incorporating physical, chemical, environmental, metabolic
and genetic factors, which play direct or indirect role in the induction and deterioration of …

The search for new compounds with a given biological activity requires enormous effort in
terms of manpower and cost. This effort arises from the large number of compounds that …

We synthesized a series of novel 5–24 derivatives of oxindole. The synthesis started from 5-
chlorooxindole, which was condensed with methyl 4-carboxybezoate and result in the …

To identify potent urease inhibitors, in the current study, a series of thioxothiazolidinyl-
acetamides were designed and synthesized. The prepared compounds were characterized …

A new group of organophosphorus inhibitors of urease, P-methyl phosphinic acids was
discovered by using the structure based inhibitor design approach. Several derivatives of …

Introduction: Urease is a nickel-containing metalloenzyme that is commonly found in
different bacteria, plants, algae, and fungi and mediates the growth of many pathogenic …

Hydroxamic acids constitute a unique family of chemicals with multiple biological activities,
because they act as potent and selective inhibitors of a large number of enzymes, such as …

Urea is the most widely used form of N fertilizer in agriculture. However, if it is not
incorporated into soil soon after application, urea has the disadvantage of undergoing …

Hydroxamic acids have emerged as the most promising candidates from among the different
classes of inhibitors of urease. In order to understand the mechanism of their action, we …

Recent developments in drug discovery have highlighted the ability of hydroxamic acids to
form complexes with various metal ions, in particular iron, zinc, magnesium and calcium …