The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …

Antagonists of the transient receptor potential vanilloid-1 (TRPV1) channel alter body
temperature (T b) in laboratory animals and humans: most cause hyperthermia; some …

Transient receptor potential vanilloid member 1 (TRPV1) is a Ca2+-permeable cation
channel that serves as the primary heat and capsaicin sensor in humans. Using cryo-EM, we …

The perception of nociceptive signals, which are translated into pain, plays a fundamental
role in the survival of organisms. Because pain is linked to a negative sensation, animals …

Transient receptor potential (TRP) ion channels are evolutionarily ancient sensory proteins
that detect and integrate a wide range of physical and chemical stimuli. TRP channels are …

Abstract Transient Receptor Potential channels from the vanilloid subfamily (TRPV) are a
group of cation channels modulated by a variety of endogenous stimuli as well as a range of …

The vanilloid receptor TRPV1 is an exquisite nociceptive sensor of noxious heat, but its
temperature-sensing mechanism is yet to define. Thermodynamics dictate that this channel …

The cation-permeable TRPV2 channel is important for cardiac and immune cell function.
Cannabidiol (CBD), a non-psychoactive cannabinoid of clinical relevance, is one of the few …

Temperature influences dynamics and state-equilibrium distributions in all molecular
processes, and only a relatively narrow range of temperatures is compatible with life …

A fundamental subdivision of nociceptive sensory neurons is named after their unique
sensitivity to capsaicin, the pungent ingredient in hot chili peppers: these are the capsaicin …