The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Hydrogen peroxide (H2O2) is widely regarded as a cytotoxic agent whose levels must be
minimized by the action of antioxidant defence enzymes. In fact, H2O2 is poorly reactive in …

Background Lysyl oxidase-like 4 (LOXL4) has been found to be dysregulated in several
human malignancies, including hepatocellular carcinoma (HCC). However, the role of …

Angiogenesis is essential for tumor growth, metastasis, arteriosclerosis as well as embryonic
development and wound healing. Its process is dependent on cell proliferation, migration …

Reactive oxygen species (ROS) are generated at sites of inflammation and injury, and at low
levels, ROS can function as signaling molecules participating as signaling intermediates in …

Ligand-receptor interactions can generate the production of hydrogen peroxide (H2O2) in
cells, the implications of which are becoming appreciated. Fluctuations in H2O2 levels can …

Once thought of as toxic by-products of cellular metabolism, reactive oxygen species (ROS)
have been implicated in a large variety of cell-signaling processes. Several enzymatic …

Angiogenesis, a process of new blood vessel formation, is a key process involved in normal
development and wound repair as well as in the various pathophysiologies such as …

Review Article such as vascular cellular adhesion molecules (VCAM-1), intracellular
adhesion molecules (ICAM-1), E-selectin and other cytokines. It is well established that NF …

Focal adhesion kinase (FAK) is an intracellular non-receptor tyrosine kinase. In addition to
its role as a major mediator of signal transduction by integrins, FAK also participates in …